58305-05-8

Upstream product

• 110-88-3 1,3,5-Trioxan 
• 94-33-7 C₉H₁₀O₃ 
• 50-00-0 formaldehyd 

Downstream Products

• 81797-05-9 5-nitroacyclouridine 
• 80504-44-5 1,2-dihydro-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine 
• 116019-29-5 Benzoic acid 2-[6-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-purin-9-ylmethoxy]-ethyl ester 
• 88713-34-2 benzoyloxy-1 cyanomethoxy-2 ethane 
• 96446-01-4 Benzoic acid 2-(2-acetylamino-4-oxo-3,4-dihydro-pyrrolo[2,3-d]pyrimidin-7-ylmethoxy)-ethyl ester 
• 96446-00-3 Benzoic acid 2-(2-acetylamino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidin-3-ylmethoxy)-ethyl ester 
• 96446-02-5 C₂₈H₂₈N₄O₈ 
• 75128-75-5 7-methylamino>-5-(methylthio)furazano<3,4-d>pyrimidine 
• 82145-28-6 5-Benzamido-1-(2-benzoyloxyethoxymethyl)-4-methylcarbamoylimidazole 
• 82145-27-5 5-Benzamido-3-(2-benzoyloxyethoxymethyl)-4-methylcarbamoylimidazole 
• 82145-26-4 5-Benzamido-1-(2-benzoyloxyethoxymethyl)-4-carbamoylimidazole 
• 82145-25-3 5-Benzamido-3-(2-benzoyloxyethoxymethyl)-4-carbamoylimidazole 
• 96445-99-7 2-<(5-amino-6,7-dihydro-7-oxo-1H-1,2,3-triazolo<4,5-d>pyrimidin-1-yl)methoxy>ethyl benzoate 
• 96445-98-6 2-<(5-amino-6,7-dihydro-7-oxo-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)methoxy>ethyl benzoate 

Relevant academic research and scientific papers

Reaction of 6-chloropyrimidine-2,4(1H,3H)-dione with 2-(chloromethoxy)ethyl benzoate. Synthesis of new acyclic nucleosides

New acyclic pyrimidine nucleosides, analogs of the antiviral drug acyclovir, were synthesized starting from 6-chloropyrimidine-2,4(1H,3H)-dione. The addition of side carbohydrate chain to the N1 or N3 atoms of the heterocyclic base w

PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES

Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases (RTs) expressed in cells of the patients are also disclosed. Method of using nucleoside analogs and other inhibitors of RTs in conjunction with DNA damaging agents such as genotoxic agents or radiation or photodynamic therapy or combinations these for the treatment of various cancers are also disclosed.

Novel pesticides, preparation and use

The specification describes and claims methods of controlling acarine pests by application of a compound of Formula (I), methods of controlling arthropod pests by application of a compound of Formula (IA), compounds of Formula (IA) per se, pesticidal compositions comprising a compound of Formula (IA), and processes for preparing a compound of Formula (IA).

Modifications on the Heterocyclic Base of Acyclovir: Syntheses and Antiviral Properties

A griup of compounds were prepared in which variations of the ring portion of the acyclovir (ACV) structure were made.These modifications included monocyclic (isocytosine, triazole, imidazole), bicyclic (8-azapurine, pyrrolo pyrimidine, pyrazolo3,

Synthesis and Biological Effects of Acyclic Pyrimidine Nucleoside Analogues

A series of nucleoside analogues has been prepared, wherein the cyclic carbohydrate moiety is replaced by aliphatic side chains attached to cytosine, thymine, uracil, and 5-fluorouracil.The 1- derivatives of these heterocycles were synthesized by reacting the silylated bases with 2-(chloromethoxy)ethyl benzoate, followed by removal of the protecting groups with methanolic ammonia.The hydroxy group of a number of these derivatives was subsequently replaced by an azido, amino, or carbamoyloxy moiety.The 1-(2-oxo-3-butyl) and 1-(2-oxo-3-nonyl)derivatives of cytosine were also prepared, their synthesis being accomplished by condensation of the silylated heterocycle with the appropriate α-halo ketone.At 10-4 M concentrations, the newly prepared compounds were inactive against leukemia L-1210 cells in culture.However, a number of the agents inhibited the in vitro growth of Escherichia coli K-12, the most potent among these, 1--5-fluorouracil, being active at an IC50 of 1.2 μM.This compound was equally active in preventing the growth of a 5-fluorouracil resistant strain of E. coli.Some of the analogues were also found the selectively interfere with herpes simplex virus replication in vitro.None of the cytosine derivatives tested served as either substrates or inhibitors of human liver citosine nucleoside deaminase.

2-Amido-9-(2-acyloxyethoxymethyl)hypoxanthines

Method of preparing 9-(2-hydroxyethoxymethyl)guanine which comprises preparing the compound STR1 wherein R and R1 are hydrogen, lower alkyl and phenyl and then hydrolyzing same. 9-(2-hydroxyethoxymethyl)guanine is useful as an antiviral.

8-Azapurine derivatives

9-Hydroxyethoxymethyl (and related) derivatives of 2-amino-6-substituted-8-azapurines have been found to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the compounds o