(S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Base Information

Chemical Name:(S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate
CAS No.:1266607-74-2
Molecular Formula:C₂₇H₂₇N₃O₅
Molecular Weight:473.528
Hs Code.:

Synonyms:(S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

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Chemical Property of (S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

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Technology Process of (S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

There total 5 articles about (S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 616-34-2
methoxycarbonylmethylamine

: (9H-fluoren-9-yl)methyl (S)-(1-(hydroxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate

: 1266607-74-2
(S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Guidance literature:: (9H-fluoren-9-yl)methyl (S)-(1-(hydroxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate; With ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h; Green chemistry;

methoxycarbonylmethylamine; In dichloromethane; for 6h; chemoselective reaction; Green chemistry;
DOI:10.1002/adsc.201600661

Reference yield:

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 611198-23-3
Fmoc-Phe-NCO

: 1266607-74-2
(S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Guidance literature:: glycine ethyl ester hydrochloride; With 4-methyl-morpholine; In dichloromethane; at 25 ℃;

Fmoc-Phe-NCO; In dichloromethane;
DOI:10.1002/jms.1862

Reference yield:

: 84890-98-2
Fmoc-Phe-O-COO-isoBu

: 1266607-74-2
(S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / tetrahydrofuran; water / 0.5 h

2: toluene / 65 °C / Inert atmosphere

3: 4-methyl-morpholine / dichloromethane / 25 °C

With 4-methyl-morpholine; sodium azide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1002/jms.1862