N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide

Base Information

Chemical Name:N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide
CAS No.:1262414-09-4
Molecular Formula:C₂₇H₃₆N₄O₆
Molecular Weight:512.606
Hs Code.:

Synonyms:N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide

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Chemical Property of N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide

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Technology Process of N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide

There total 8 articles about N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1262414-09-4
N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / 24 h / Reflux

3.1: Pd(dppf) / tetrahydrofuran / 18 h / 85 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / 20 °C

5.2: 0.5 h / 20 °C

6.1: 1,4-dioxane / 2 h / 100 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 3.1: Negishi Coupling Reaction;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1262414-09-4
N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Pd(dppf) / tetrahydrofuran / 18 h / 85 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: 1,4-dioxane / 2 h / 100 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Pd(dppf); In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 1.1: Negishi Coupling Reaction;

Reference yield:

: 1122089-63-7
2-methoxy-6-(pentan-3-yl)isonicotinic acid

: 1150644-81-7
(S)-N-(-3-[2-chloro-4-(N-hydroxycarbamimidoyl)-6-methyl-phenoxy]-2-hydroxy-propyl)-2-hydroxy-acetamide

: 1262414-09-4
N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide

Guidance literature:: 2-methoxy-6-(pentan-3-yl)isonicotinic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(S)-N-(-3-[2-chloro-4-(N-hydroxycarbamimidoyl)-6-methyl-phenoxy]-2-hydroxy-propyl)-2-hydroxy-acetamide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;