42521-10-8

Basic information

• Product Name: METHYL 2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLATE
• Synonyms: METHYL 2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLATE;methyl 2-chloro-6-methoxyisonicotinate;2-Chloro-6-methoxyisonicotinic acid methyl ester;Methyl 2-chloro-6-methoxypyridine-4-carboxylate, 2-Chloro-6-methoxy-4-(methoxycarbonyl)pyridine;Methyl 2-chloro-6-methoxyisonicotinate 2-Chloro-6-methoxyisonicotinic acid methyl ester;2-(2-chloro-6-methoxypyridin-4-yl)acetic acid
• CAS NO: 42521-10-8
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.61
• Mol File: 42521-10-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 97.5°
• Boiling Point: 281℃
• Flash Point: 124℃
• Appearance: /
• Density: 1.288
• Vapor Pressure: 0.00353mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: METHYL 2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLATE(42521-10-8)
• EPA Substance Registry System: METHYL 2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLATE(42521-10-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42521-10-8(Hazardous Substances Data)

Usage

General Description

Methyl 2-chloro-6-methoxypyridine-4-carboxylate is a chemical compound with the molecular formula C8H8ClNO3. It is a pyridine derivative that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. METHYL 2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLATE is often used in the production of fungicides and herbicides due to its potent biological activity. It is an important building block in organic synthesis and can be utilized in the creation of various pharmaceutical products. Additionally, it is known for its high level of purity and stability, making it a valuable component in the chemical industry.

InChI:InChI=1/C8H8ClNO3/c1-12-7-4-5(8(11)13-2)3-6(9)10-7/h3-4H,1-2H3

Upstream product

• 99-11-6 citrazinic acid 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 67-56-1 methanol 
• 42521-09-5 methyl 2,6-dichloroisonicotinate 
• 15855-06-8 2-chloro-6-methoxy-isonicotinic acid 
• 74-88-4 methyl iodide 
• 124-41-4 sodium methylate 

Downstream Products

• 1011264-11-1 2-isobutyl-6-methoxy-isonicotinic acid methyl ester 
• 1220166-50-6 methyl 2-methoxy-6-(methylthio)isonicotinate 
• 1122089-63-7 2-methoxy-6-(pentan-3-yl)isonicotinic acid 
• 1262414-17-4 N-(2-chloro-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenyl)-methanesulfonamide 
• 1262414-03-8 4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine 
• 1262414-02-7 (S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol 
• 1262414-09-4 N-[(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-1,2,4-oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-acetamide 
• 1262414-13-0 2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenol 
• 1262414-14-1 4-[(2S)-3-(3-ethyl-5-methyl-4-oxiranylmethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-(1-ethyl-propyl)-6-methoxy-pyridine 
• 1262414-15-2 (2S)-1-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-3-methylamino-propan-2-ol 
• 1262414-12-9 N-[(2S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-2-hydroxy-propyl]-2-hydroxy-N-methyl-acetamide 

Relevant articles and documents

S1P1 AGONIST AND APPLICATION THEREOF

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Design and structural analysis of aromatic inhibitors of type II dehydroquinase from mycobacterium tuberculosis

3-Dehydroquinase, the third enzyme in the shikimate pathway, is a potential target for drugs against tuberculosis. Whilst a number of potent inhibitors of the Mycobacterium tuberculosis enzyme based on a 3-dehydroquinate core have been identified, they generally show little or no in vivo activity, and were synthetically complex to prepare. This report describes studies to develop tractable and drug-like aromatic analogues of the most potent inhibitors. A range of carbon-carbon linked biaryl analogues were prepared to investigate the effect of hydrogen bond acceptor and donor patterns on inhibition. These exhibited inhibitory activity in the high-micromolar range. The addition of flexible linkers in the compounds led to the identification of more potent 3-nitrobenzylgallate- and 5-aminoiso-phthalate-based analogues.