(E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime

Base Information

• Chemical Name: (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime
• CAS No.: 1239586-80-1
• Molecular Formula: C₁₂H₁₂N₂OS
• Molecular Weight: 232.306
• Mol file: 1239586-80-1.mol

Synonyms:(E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime

Chemical Property of (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime

There total 1 articles about (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(E)-3-ethynylcyclohex-2-enoneoxime (1224432-90-9) + 4-bromo-2-methyl-1,3-thiazole (298694-30-1) → (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime (1239586-80-1)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 26h;

DOI:10.1039/c2md20332d

Reference yield: 72.0%

(2-(2-bromoethoxy)ethoxy)(tert-butyl)dimethylsilane + (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime (1239586-80-1) → (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone o-2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethyl oxime (1239586-84-5)

Guidance literature:

(E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

(2-(2-bromoethoxy)ethoxy)(tert-butyl)dimethylsilane; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2010.06.070

Reference yield:

[11C]methyl iodide (54245-42-0) + (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone oxime (1239586-80-1) → (E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone O-11C-methyl oxime

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 90 ℃; for 0.05h; Inert atmosphere;

DOI:10.1039/c2md20332d

upstream raw materials:

(E)-3-ethynylcyclohex-2-enoneoxime

4-bromo-2-methyl-1,3-thiazole

Downstream raw materials:

(E)-3-((2-methylthiazol-4-yl)ethynyl)cyclohex-2-enone o-2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethyl oxime