Multi-step reaction with 9 steps
1.1: ethanol / tin(II) chloride hydrate / 0.5 h / 70 °C
2.1: dmap / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3.1: potassium hydroxide / ethanol / 0.5 h / 20 °C
3.2: 1 h / 20 °C
4.1: Oxone / acetonitrile; water / 18 h / 20 °C
5.1: potassium dihydrogenphosphate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 17 h / 100 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C / Cooling with ice
7.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
8.1: triethylamine / copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 24 h / 50 °C / Inert atmosphere; Cooling with ice
9.1: formic acid; potassium hydrogensulfate / water / 4 h / 50 °C / Inert atmosphere
With
Oxone; potassium hydrogensulfate; potassium dihydrogenphosphate; formic acid; ethanol; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tin(II) chloride hydrate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;