N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Base Information

• Chemical Name: N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide
• CAS No.: 446234-38-4
• Molecular Formula: C₂₂H₃₁N₅O₅S
• Molecular Weight: 477.585

Synonyms:N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Chemical Property of N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

There total 6 articles about N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → N4-acetyl{N1-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide (446234-38-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 4-methylmorpholine; isobutyl chloroformate; triethylamine / tetrahydrofuran; dimethylformamide / -15 - 20 °C

2: tetrahydrofuran; diethyl ether / -78 - 20 °C

3: aq. NaOH / ethanol / 3 h / Heating

4: pyridine / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jf0200624

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N4-acetyl{N1-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide (446234-38-4)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaOH / dioxane / 5 h

2: 4-methylmorpholine; isobutyl chloroformate; triethylamine / tetrahydrofuran; dimethylformamide / -15 - 20 °C

3: tetrahydrofuran; diethyl ether / -78 - 20 °C

4: aq. NaOH / ethanol / 3 h / Heating

5: pyridine / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jf0200624

Reference yield:

6-aminohexanoic acid (60-32-2,93208-38-9) → N4-acetyl{N1-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide (446234-38-4)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaOH / dioxane / 5 h

2: 4-methylmorpholine; isobutyl chloroformate; triethylamine / tetrahydrofuran; dimethylformamide / -15 - 20 °C

3: tetrahydrofuran; diethyl ether / -78 - 20 °C

4: aq. NaOH / ethanol / 3 h / Heating

5: pyridine / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jf0200624

upstream raw materials:

p-acetylaminobenzenesulfonyl chloride

{2-amino-[4-(5-N-tert-butyloxycarbonylamino)pentyl]}pyrimidine

di-tert-butyl dicarbonate

6-(tert-butoxycarbonylamino)hexanoic acid

Downstream raw materials:

N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

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