N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea

Base Information

• Chemical Name: N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea
• CAS No.: 1305317-17-2
• Molecular Formula: C₂₆H₁₉N₅O
• Molecular Weight: 417.47
• Mol file: 1305317-17-2.mol

Synonyms:N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea

Chemical Property of N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea

There total 12 articles about N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

8-amino-2,3-diphenylpyrido[3,4-b]pyrazine (788821-74-9) + phenyl isocyanate (103-71-9) → N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea (1305317-17-2)

Guidance literature:

8-amino-2,3-diphenylpyrido[3,4-b]pyrazine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

phenyl isocyanate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 7h;

DOI:10.1055/s-0030-1259429

Reference yield:

3,4-diaminopyridine (54-96-6) → N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea (1305317-17-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,4-dioxane / 120 h / Reflux

2.1: hydrogen bromide; dihydrogen peroxide / water / 1 h / 80 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; sodium t-butanolate / toluene / 12 h / 100 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 48 h / 75 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 7 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; rac-BINAP; hydroxylamine hydrochloride; hydrogen bromide; dihydrogen peroxide; sodium acetate; sodium hydride; sodium t-butanolate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 3.1: Buchwald reaction;

DOI:10.1055/s-0030-1259429

Reference yield:

3,4,5-triaminopyridine (618439-82-0) → N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea (1305317-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 6 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 7 h / 20 °C

With sodium hydride; sodium hydrogencarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1055/s-0030-1259429

upstream raw materials:

3,4-diaminopyridine

3,4,5-triaminopyridine

3,4-diamino-5-bromopyridine

4-(nitroamino)pyridine