618439-82-0

Basic information

• Product Name: PYRIDINE-3,4,5-TRIAMINE
• Synonyms: PYRIDINE-3,4,5-TRIAMINE;3,4,5-Pyridinetriamine;3,4,5-Triaminopyridine;3,4,5-Triminopyridine
• CAS NO: 618439-82-0
• Molecular Formula: C₅H₈N₄
• Molecular Weight: 124.146
• EINECS: -0
• Mol File: 618439-82-0.mol

Chemical Properties

• Boiling Point: 486.8°C at 760 mmHg
• Flash Point: 280.1°C
• Appearance: /
• Density: 1.387
• Vapor Pressure: 1.25E-09mmHg at 25°C
• Refractive Index: 1.766
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.08±0.24(Predicted)
• CAS DataBase Reference: PYRIDINE-3,4,5-TRIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE-3,4,5-TRIAMINE(618439-82-0)
• EPA Substance Registry System: PYRIDINE-3,4,5-TRIAMINE(618439-82-0)

Safety Data

• Hazardous Substances Data: 618439-82-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
PYRIDINE-3,4,5-TRIAMINE is used as a building block for the synthesis of various pharmaceuticals, due to its versatile chemical structure and reactivity.
Used in Agrochemical Industry:
PYRIDINE-3,4,5-TRIAMINE is used as a precursor in the production of agrochemicals, contributing to the development of effective crop protection agents.
Used in Dye Synthesis:
PYRIDINE-3,4,5-TRIAMINE is used as a precursor for the synthesis of dyes, enabling the creation of a wide range of colorants for various applications.
Used in Coating Production:
PYRIDINE-3,4,5-TRIAMINE is used as a component in the formulation of coatings, enhancing their properties and performance.
Used in Polymer Synthesis:
PYRIDINE-3,4,5-TRIAMINE is used as a monomer or intermediate in the synthesis of polymers, contributing to the development of new materials with specific properties.
Used in Corrosion Inhibition:
PYRIDINE-3,4,5-TRIAMINE is used as a corrosion inhibitor, providing protection to metal surfaces in various industrial applications.
Used in Antioxidant Formulation:
PYRIDINE-3,4,5-TRIAMINE is used in the development of antioxidants, helping to prevent the degradation of materials and extend their lifespan.
Used in Flame Retardant Production:
PYRIDINE-3,4,5-TRIAMINE is used in the manufacture of flame retardants, improving the fire safety of various materials.

InChI:InChI=1/C5H8N4/c6-3-1-9-2-4(7)5(3)8/h1-2H,6-7H2,(H2,8,9)

Upstream product

• 4318-68-7 3,4-diamino-5-nitropyridine 
• 31793-29-0 4-Amino-3,5-dinitropyridine 
• 504-24-5 4-aminopyridine 

Downstream Products

• 120208-34-6 pyrido[3,4-b]pyrazin-8-ylamine 
• 109868-80-6 2,3-dimethyl-pyrido[3,4-b]pyrazin-8-ylamine 
• 906461-83-4 2-(4-tert-butyl-phenyl)-3H-imidazo[4,5-c]pyridin-7-ylamine 
• 1305317-16-1 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylurea 
• 1305317-17-2 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea 
• 1305317-18-3 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-(3-methoxyphenyl)urea 
• 1305317-19-4 N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)urea 
• 1305317-20-7 N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)urea 
• 1305317-22-9 N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea 
• 1305317-24-1 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea 
• 1305317-25-2 N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-ethylthiourea 
• 1305317-29-6 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N,N'-diethyldicarbonimidic diamide 
• 1305317-26-3 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)acetamide 
• 1305317-27-4 N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]acetamide 

Relevant articles and documents

Preparation of novel 2,3,8-trisubstituted pyrido[3,4-b]pyrazines and pyrido[2,3-b]pyrazines

A four-step synthesis of 8-bromo-2,3-disubstituted pyrido[3,4-b]pyrazines and a six-step synthesis of 8-amino-2,3-disubstituted pyrido[3,4-b]pyrazines have been developed. A particularly valuable feature of this synthetic route is the possibility to build

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists based on a 4-piperazinylbenzimidazole template, we sought to investigate the properties of heterocyclic isosteres of the benzimidazole template. We report here the synthesis and biological activity of eight novel scaffolds, including imidazopyridines, benzothiazoles and benzoxazoles. The 2-(4-tert-butylphenyl)-8-(piperazin-1-yl)imidazo[1,2-a]pyridine ring system was shown to have nanomolar binding potency at the human and rat GnRH receptors as well as functional antagonism in vitro. Additional structure-activity relationships within this series are reported along with a pharmacokinetic comparison to the benzimidazole-based lead molecule.

7-SUBSTITUTED IMIDAZO[4,5-C]PYRIDINE ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE RECEPTOR

The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.

Diaminopyridine compounds and methods of use

The present invention relates to compositions and method for inhibiting nonenzymatic cross-linking (protein aging) which contain diaminopyridines and derivates thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.