di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate

Base Information

Chemical Name:di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate
CAS No.:1350351-57-3
Molecular Formula:C₃₈H₄₈N₄O₈S
Molecular Weight:720.887
Hs Code.:

Synonyms:di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate

Suppliers and Price of di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate

There total 6 articles about di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 317358-61-5
tert-butyl (3-bromo-benzyl)-N-methylcarbamate

: 1232423-98-1
tert-butyl N-(3-ethynyl-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)N-tertbutoxycarbonyl-carbamate ?

: 1350351-57-3
di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate

Guidance literature:: With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h; Sealed tube;

Reference yield:

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1350351-57-3
di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile; water / 1 h / 60 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 0 °C / Cooling with ice

3.2: 2.17 h / 20 °C / Cooling with ice

4.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

5.1: sodium carbonate / water; methanol / 1 h / 20 °C

6.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1.5 h / 100 °C / Sealed tube

With dmap; potassium phosphate; N-Bromosuccinimide; sodium carbonate; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1349151-81-0
5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1350351-57-3
di-tert-butyl 3-((3-((tert-butoxycarbonyl(methyl)amino)methyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yliminodicarbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 0 °C / Cooling with ice

2.2: 2.17 h / 20 °C / Cooling with ice

3.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

4.1: sodium carbonate / water; methanol / 1 h / 20 °C

5.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1.5 h / 100 °C / Sealed tube

With dmap; N-Bromosuccinimide; sodium carbonate; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; N,N-dimethyl-formamide;