Technology Process of 8-methoxy-9-[2-(4-phenylpiperazino)ethoxy]-(13aS)-1,2,3,13a-tetrahydro-5H-pyrrolo[2,1-c][1,4]naphthodiazepin-5-one
There total 15 articles about 8-methoxy-9-[2-(4-phenylpiperazino)ethoxy]-(13aS)-1,2,3,13a-tetrahydro-5H-pyrrolo[2,1-c][1,4]naphthodiazepin-5-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
calcium carbonate; mercury dichloride;
In
water; acetonitrile;
at 27 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: hydrogenchloride / water; 1,4-dioxane / 2 h / Cooling with ice
2.1: sodium acetate / 2 h / Reflux
3.1: ammonia / methanol / 15 h
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
4.2: 0.17 h / -78 °C
5.1: sodium ethanolate / ethanol / 16 h / 0 - 20 °C / Cooling with ice
6.1: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 6 h / 27 °C
7.1: thionyl chloride; N,N-dimethyl-formamide / benzene / 20 °C / Inert atmosphere
7.2: 0 °C
8.1: diisobutylaluminium hydride / dichloromethane / 0.75 h / -78 °C
8.2: 12 h / 27 °C
9.1: potassium carbonate / 1 h / 120 °C
10.1: tin(II) chloride dihdyrate / methanol / 5 h / 65 °C
11.1: mercury dichloride; calcium carbonate / acetonitrile; water / 12 h / 27 °C
With
hydrogenchloride; thionyl chloride; oxalyl dichloride; tin(II) chloride dihdyrate; lithium hydroxide monohydrate; ammonia; sodium ethanolate; sodium acetate; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; N,N-dimethyl-formamide; calcium carbonate; mercury dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile; benzene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: ammonia / methanol / 15 h
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
2.2: 0.17 h / -78 °C
3.1: sodium ethanolate / ethanol / 16 h / 0 - 20 °C / Cooling with ice
4.1: lithium hydroxide monohydrate / tetrahydrofuran; water; methanol / 6 h / 27 °C
5.1: thionyl chloride; N,N-dimethyl-formamide / benzene / 20 °C / Inert atmosphere
5.2: 0 °C
6.1: diisobutylaluminium hydride / dichloromethane / 0.75 h / -78 °C
6.2: 12 h / 27 °C
7.1: potassium carbonate / 1 h / 120 °C
8.1: tin(II) chloride dihdyrate / methanol / 5 h / 65 °C
9.1: mercury dichloride; calcium carbonate / acetonitrile; water / 12 h / 27 °C
With
thionyl chloride; oxalyl dichloride; tin(II) chloride dihdyrate; lithium hydroxide monohydrate; ammonia; sodium ethanolate; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; N,N-dimethyl-formamide; calcium carbonate; mercury dichloride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile; benzene;
