2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride

Base Information

Chemical Name:2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride
CAS No.:1082063-19-1
Molecular Formula:C₂₂H₂₈N₆O₂*ClH
Molecular Weight:444.964
Hs Code.:

Synonyms:2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride

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Chemical Property of 2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride

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Technology Process of 2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride

There total 3 articles about 2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1082066-14-5
2-[4-(3'-chloro-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl)-pyrazol-1-yl]-ethanol

: 279262-11-2
(4-(methoxymethyl)phenyl)boronic acid

: 1082063-19-1
2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride

Guidance literature:: 2-[4-(3'-chloro-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl)-pyrazol-1-yl]-ethanol; (4-(methoxymethyl)phenyl)boronic acid; With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris[tert-butyl]phosphonium tetrafluoroborate; In tetrahydrofuran; water; at 150 ℃; for 0.25h; Microwave irradiation;

With ammonium chloride; In methanol; for 0.166667h;

Reference yield:

: 313654-83-0
2-Chloro-3-(4-tert-butoxycarbonyl-1-piperazinyl)pyrazine

: 1082063-19-1
2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 h / 20 °C

3.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris[tert-butyl]phosphonium tetrafluoroborate / tetrahydrofuran; water / 0.25 h / 150 °C / Microwave irradiation

3.2: 0.17 h

With hydrogenchloride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris[tert-butyl]phosphonium tetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane; 3.1: Suzuki Coupling;

Reference yield:

: 1082065-98-2
1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde

: 85386-99-8
1-(3-chloro-2-pyrazinyl)piperazine

: 1082063-19-1
2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 h / 20 °C

2.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris[tert-butyl]phosphonium tetrafluoroborate / tetrahydrofuran; water / 0.25 h / 150 °C / Microwave irradiation

2.2: 0.17 h

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris[tert-butyl]phosphonium tetrafluoroborate; In tetrahydrofuran; water; 1,2-dichloro-ethane; 2.1: Suzuki Coupling;