benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate

Base Information

Chemical Name:benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate
CAS No.:1415221-96-3
Molecular Formula:C₄₀H₄₄N₂O₅
Molecular Weight:632.8
Hs Code.:

Synonyms:benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate

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Chemical Property of benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate

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Technology Process of benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate

There total 2 articles about benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17734-22-4
7--phenylheptan--1--amine

: 122350-52-1
(4S)-5-benzyloxy-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid

: 1415221-96-3
benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate

Guidance literature:: (4S)-5-benzyloxy-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

7--phenylheptan--1--amine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.10.093

Reference yield:

: 3208-25-1
7-phenylheptan-1-ol

: 1415221-96-3
benzyl N--Fmoc--(2S)--2--amino--5--oxo--5--((7--phenylheptyl)amino)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 4 h

2.1: sodium azide / N,N-dimethyl-formamide / 10 h / 60 °C

3.1: magnesium / methanol / 1 h / 0 °C

4.1: HATU; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With sodium azide; benzotriazol-1-ol; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.093