3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid

Base Information

Chemical Name:3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid
CAS No.:1093631-50-5
Molecular Formula:C₂₈H₂₁Cl₂NO₄S
Molecular Weight:538.451
Hs Code.:

Synonyms:3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid

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Chemical Property of 3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid

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Technology Process of 3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid

There total 7 articles about 3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₃Cl₂NO₄S

: 1093631-50-5
3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid

Guidance literature:: C₂₉H₂₃Cl₂NO₄S; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 72h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

Reference yield:

: 2060-64-2
benzo[b]thiophene-5-carboxylic acid

: 1093631-50-5
3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; acetic acid / 20 h / 20 °C

2: thionyl chloride / 1 h / Reflux

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 2.5 h / 90 °C

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

5: water; sodium hydroxide / tetrahydrofuran; ethanol / 72 h / 20 °C

With thionyl chloride; water; bromine; sodium carbonate; potassium carbonate; acetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; 3: Suzuki Coupling;

Reference yield:

: 1005206-97-2
methyl 3-bromo-1-benzothiophene-5-carboxylate

: 1093631-50-5
3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 2.5 h / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

3: water; sodium hydroxide / tetrahydrofuran; ethanol / 72 h / 20 °C

With water; sodium carbonate; potassium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; 1: Suzuki Coupling;