2060-64-2

Basic information

• Product Name: 1-BENZOTHIOPHENE-5-CARBOXYLIC ACID
• Synonyms: BUTTPARK 98\04-76;1-BENZOTHIOPHENE-5-CARBOXYLIC ACID;5-CARBOXYBENZO[B]THIOPHENE;5-BENZOTHIOPHENECARBOXALDEHYDE;Benzo[b]thiophene-5-carboxylic acid;Benzothiophene-5-carboxylic acid
• CAS NO: 2060-64-2
• Molecular Formula: C₉H₆O₂S
• Molecular Weight: 178.21
• Mol File: 2060-64-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 211℃
• Boiling Point: 376.2 °C at 760 mmHg
• Flash Point: 181.3 °C
• Appearance: /
• Density: 1.419 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.13±0.30(Predicted)
• CAS DataBase Reference: 1-BENZOTHIOPHENE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOTHIOPHENE-5-CARBOXYLIC ACID(2060-64-2)
• EPA Substance Registry System: 1-BENZOTHIOPHENE-5-CARBOXYLIC ACID(2060-64-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 2060-64-2(Hazardous Substances Data)

Usage

General Description

1-Benzothiophene-5-carboxylic acid is a chemical compound with the formula C9H6O2S. It is a heterocyclic carboxylic acid that contains both a benzene ring and a thiophene ring. 1-BENZOTHIOPHENE-5-CARBOXYLIC ACID is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, and it is also used as a building block in the synthesis of organic compounds. 1-Benzothiophene-5-carboxylic acid has been studied for its potential biological and pharmacological properties, including its anti-inflammatory and anti-bacterial activities. It is an important compound in organic chemistry and is used in various industries for the production of a wide range of products.

Upstream product

• 4923-87-9 5-bromobenzo[b]thiophene 
• 124-38-9 carbon dioxide 
• 584-08-7 potassium carbonate 

Downstream Products

• 1128-89-8 benzo[b]thiophene-5-carbonyl chloride 
• 1407994-22-2 C₂₀H₁₅ClN₂OS 
• 20532-39-2 methyl benzothiophene-5-carboxylate 
• 20532-34-7 5-(hydroxymethyl)benzothiophene 
• 10133-30-9 benzo[b]thiophene-5-carbaldehyde 
• 1093631-50-5 3-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-5-carboxylic acid 
• 1093631-79-8 methyl 3-(4-hydroxyphenyl)-1-benzothiophene-5-carboxylate 
• 1005206-97-2 methyl 3-bromo-1-benzothiophene-5-carboxylate 
• 1225021-83-9 N-phenylbenzo[b]thiophene-5-carboxamide 

Relevant articles and documents

Carboxylation of Aromatic and Aliphatic Bromides and Triflates with CO2 by Dual Visible-Light–Nickel Catalysis

We report the efficient carboxylation of bromides and triflates with K2CO3 as the source of CO2 in the presence of an organic photocatalyst in combination with a nickel complex under visible light irradiation at room temperature. The reaction is compatible with a variety of functional groups and has been successfully applied to the synthesis and derivatization of biologically active molecules. In particular, the carboxylation of unactivated cyclic alkyl bromides proceeded well with our protocol, thus extending the scope of this transformation. Spectroscopic and spectroelectrochemical investigations indicated the generation of a Ni0 species as a catalytic reactive intermediate.