3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine

Base Information

Chemical Name:3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine
CAS No.:917898-94-3
Molecular Formula:C₁₈H₁₇ClFN₃
Molecular Weight:329.804
Hs Code.:

Synonyms:3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine

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Chemical Property of 3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine

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Technology Process of 3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine

There total 6 articles about 3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 917898-99-8
3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

: 917898-94-3
3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine

Guidance literature:: 3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide; With aluminum (III) chloride; lithium aluminium tetrahydride; In diethyl ether; toluene; at 65 ℃; for 68h;

With sodium hydroxide; water; In diethyl ether; toluene;

Reference yield:

: 917898-97-6
3-(4-bromo-phenyl)-3-(4-chloro-3-fluoro-phenyl)-propionic acid

: 917898-94-3
3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 1 h / 50 °C

1.2: 64 h / 20 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 0.5 h / 145 °C / Microwave irradiation

3.1: aluminum (III) chloride; lithium aluminium tetrahydride / diethyl ether; toluene / 68 h / 65 °C

With aluminum (III) chloride; potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; diethyl ether; ethanol; water; toluene;

Reference yield:

: 917898-95-4
3-(4-bromo-phenyl)-3-(4-chloro-3-fluoro-phenyl)-2-cyano-propionic acid ethyl ester

: 917898-94-3
3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; water; acetic acid / 2.5 h / Heating / reflux

2.1: thionyl chloride / 1 h / 50 °C

2.2: 64 h / 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 0.5 h / 145 °C / Microwave irradiation

4.1: aluminum (III) chloride; lithium aluminium tetrahydride / diethyl ether; toluene / 68 h / 65 °C

With aluminum (III) chloride; potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; water; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; diethyl ether; ethanol; water; toluene;