3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Base Information

Chemical Name:3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide
CAS No.:917898-99-8
Molecular Formula:C₁₈H₁₅ClFN₃O
Molecular Weight:343.788
Hs Code.:

Synonyms:3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

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Chemical Property of 3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Chemical Property:

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Technology Process of 3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

There total 4 articles about 3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917898-97-6
3-(4-bromo-phenyl)-3-(4-chloro-3-fluoro-phenyl)-propionic acid

: 917898-99-8
3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 1 h / 50 °C

1.2: 64 h / 20 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 0.5 h / 145 °C / Microwave irradiation

With potassium phosphate; thionyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene;

Reference yield:

: 917898-95-4
3-(4-bromo-phenyl)-3-(4-chloro-3-fluoro-phenyl)-2-cyano-propionic acid ethyl ester

: 917898-99-8
3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; water; acetic acid / 2.5 h / Heating / reflux

2.1: thionyl chloride / 1 h / 50 °C

2.2: 64 h / 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 0.5 h / 145 °C / Microwave irradiation

With potassium phosphate; thionyl chloride; sulfuric acid; water; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene;

Reference yield:

: 42205-33-4
(E)-ethyl 3-(4-bromophenyl)-2-cyanoacrylate

: 917898-99-8
3-(4-chloro-3-fluoro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; toluene / 16 h / 0 - 70 °C

1.2: 0 °C

2.1: sulfuric acid; water; acetic acid / 2.5 h / Heating / reflux

3.1: thionyl chloride / 1 h / 50 °C

3.2: 64 h / 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 0.5 h / 145 °C / Microwave irradiation

With potassium phosphate; thionyl chloride; sulfuric acid; water; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; toluene;