9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline

Base Information

Chemical Name:9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline
CAS No.:172268-92-7
Molecular Formula:C₂₉H₃₆N₂O₃Si
Molecular Weight:488.702
Hs Code.:

9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopent<g>isoquinoline

Synonyms:9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline

Suppliers and Price of 9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline

There total 9 articles about 9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 172268-85-8
9-(benzyloxy)-8-cyano-1-ethoxy-3-(hydroxymethyl)-7,8-dihydro-6H-cyclopentisoquinoline

: 172268-92-7
9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 0.75h;
DOI:10.1021/ja00153a004

Reference yield:

: 141903-26-6
3,6-bis(ethoxycarbonyl)-2-ethoxy-4-methylpyridine

: 172268-92-7
9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA, 3.) EtOH

2: 87 percent / DDQ / CH₂Cl₂ / 0.17 h / 25 °C

3: 93 percent / K₂CO₃, Bu₄NI / dimethylformamide / 6 h / 25 °C

4: t-BuOK, EtOH / CH₂Cl₂ / 7 h / -67 - 25 °C

5: 68 percent / Et₃N, DMAP

6: 92 percent / Dibal-H / tetrahydrofuran; toluene / 3 h / -78 °C

7: 85 percent / imidazole / dimethylformamide / 0.75 h / 25 °C

With 1H-imidazole; dmap; ethanol; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00153a004

Reference yield:

: 1035804-85-3
3,6-bis(ethoxycarbonyl)-2,2-diethoxy-4-methyl-1-(methylsulfonyl)-1,2,3,4-tetrahydropyridine

: 172268-92-7
9-(benzyloxy)-8-cyano-1-ethoxy-3-((tert-butyldimethylsilyloxy)methyl)-7,8-dihydro-6H-cyclopentisoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1: 83 percent / DBU / tetrahydrofuran / 40 h / 70 °C

2: 1.) LDA, 3.) EtOH

3: 87 percent / DDQ / CH₂Cl₂ / 0.17 h / 25 °C

4: 93 percent / K₂CO₃, Bu₄NI / dimethylformamide / 6 h / 25 °C

5: t-BuOK, EtOH / CH₂Cl₂ / 7 h / -67 - 25 °C

6: 68 percent / Et₃N, DMAP

7: 92 percent / Dibal-H / tetrahydrofuran; toluene / 3 h / -78 °C

8: 85 percent / imidazole / dimethylformamide / 0.75 h / 25 °C

With 1H-imidazole; dmap; ethanol; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00153a004