5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole

Base Information

Chemical Name:5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole
CAS No.:1146943-42-1
Molecular Formula:C₁₂H₁₁F₄N₃OS
Molecular Weight:321.298
Hs Code.:

Synonyms:5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole

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Chemical Property of 5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole

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Technology Process of 5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole

There total 1 articles about 5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenylhydrazine

: 16130-58-8
cyanoacetic acid chloride

: 1146943-42-1
5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole

Guidance literature:: 2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenylhydrazine; cyanoacetic acid chloride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

With methanesulfonic acid; In propan-1-ol; for 3h; Reflux;

With sodium hydrogencarbonate; In water; pH=7;

Reference yield:

: 1146943-42-1
5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole

: 75-36-5
acetyl chloride

: 1146686-10-3
3-acetoxy-5-(N,N-diacetylamino)-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}pyrazole

Guidance literature:: In toluene; for 12h; Reflux;

Reference yield:

: 1146943-42-1
5-amino-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl}-3-hydroxypyrazole

: 1146689-06-6
5-acetylamino-3-[2,2-difluoro-2-{2-trifluoromethoxy-(1,1,2,2-tetrafluoroethoxy)}ethoxy]-1-{2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl}pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 12 h / Reflux

2: ammonia; water / ethanol / 0.5 h / 20 °C

3: potassium carbonate / dimethyl sulfoxide / 12 h / 20 °C

4: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.5 h / cooling with ice

With ammonia; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; chloroform; dimethyl sulfoxide; toluene;