(4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

Base Information

Chemical Name:(4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone
CAS No.:210964-91-3
Molecular Formula:C₂₈H₃₇Cl₂NO₂
Molecular Weight:490.513
Hs Code.:

Synonyms:(4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

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Chemical Property of (4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

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Technology Process of (4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

There total 1 articles about (4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 210964-88-8
(+)-(2S,3R)-2-benzyl-4,4-dichloro-3-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]cyclobutanone

: 210964-91-3
(4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

Guidance literature:: With mesitylenesulfonylhydroxylamine; In dichloromethane; at 20 ℃; for 0.666667h;
DOI:10.1021/jo9801162

Reference yield:

: 210964-91-3
(4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

: 125356-66-3,119463-16-0
(+)-preussin

Guidance literature:: Multi-step reaction with 5 steps

1: NH₄Cl, Zn-Co couple / methanol / 2 h / 20 °C

2: 100 percent / N,N-diisopropylethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 20 °C

3: 2.) triethylsilane, boron trifluoride etherate / 1) THF, -80 deg C, 30 min; 2) CH₂Cl₂, -90 to -40 deg C (slowly), -40 deg C, 1 h

4: 100 percent / CF₃COOH / 1 h / 20 °C

5: 78 percent / acetic acid, sodium cyanoborohydride / acetonitrile / 4 h / 20 °C

With triethylsilane; dmap; boron trifluoride diethyl etherate; cobalt; sodium cyanoborohydride; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo9801162