(+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

Base Information

Chemical Name:(+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone
CAS No.:210964-89-9
Molecular Formula:C₂₈H₃₉NO₂
Molecular Weight:421.623
Hs Code.:

Synonyms:(+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

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Chemical Property of (+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

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Technology Process of (+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

There total 1 articles about (+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 210964-91-3
(4R,5S)-5-benzyl-3,3-dichloro-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

: 210964-89-9
(+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

Guidance literature:: With cobalt; ammonium chloride; zinc; In methanol; at 20 ℃; for 2h; Yield given;
DOI:10.1021/jo9801162

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 210964-89-9
(+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

: 210964-93-5
(2S,3S)-2-Benzyl-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo9801162

Reference yield:

: 210964-89-9
(+)-(4S,5S)-5-benzyl-4-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]-2-pyrrolidinone

: 125356-66-3,119463-16-0
(+)-preussin

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / N,N-diisopropylethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 20 °C

2: 2.) triethylsilane, boron trifluoride etherate / 1) THF, -80 deg C, 30 min; 2) CH₂Cl₂, -90 to -40 deg C (slowly), -40 deg C, 1 h

3: 100 percent / CF₃COOH / 1 h / 20 °C

4: 78 percent / acetic acid, sodium cyanoborohydride / acetonitrile / 4 h / 20 °C

With triethylsilane; dmap; boron trifluoride diethyl etherate; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jo9801162