(4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal

Base Information

Chemical Name:(4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal
CAS No.:161006-59-3
Molecular Formula:C₂₅H₄₄O₄Si
Molecular Weight:436.707
Hs Code.:

Synonyms:(4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal

Suppliers and Price of (4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal

There total 2 articles about (4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 5707-04-0
Phenylselenyl chloride

: 161006-57-1
(4aR,5R,8aR)-3,4,4a,5,8,8a-hexahydro-5,8a-dimethyl-5-(2'-triisopropylsiloxyethyl)-6-trimethylsiloxynaphthalen-1(2H)-one ethylene ketal

: 161006-59-3
(4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal

: (4aR,5R,8aR)-3,4,4a,5,8,8a-hexahydro-5,8a-dimethyl-7-phenylselanyl-5-(2'-triisopropylsiloxyethyl)naphthalene-1,6(2H,7H)-dione ethylene ketal

Guidance literature:: In dichloromethane; for 0.0833333h;

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 161006-59-3
(4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / 2,6-Lutidine

2: 94 percent / -20 °C / Jones oxidation

3: LDA / hexamethylphosphoric acid triamide

4: CH₂Cl₂ / -78 °C

5: 67 percent / H₂O₂, Py / CH₂Cl₂

With pyridine; 2,6-dimethylpyridine; dihydrogen peroxide; lithium diisopropyl amide; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/0040-4039(94)88279-7

Reference yield:

: 161006-59-3
(4aR,5R,8aR)-4a,5,6,7-tetrahydro-4,8a-dimethyl-4-(2'-triisopropylsiloxyethyl)naphthalene-3,8(4H,8aH)-dione 8-ethylene ketal

: 141979-19-3,92593-91-4
16-hydroxycleroda-3,13-dien-15,16-olide

Guidance literature:: Multi-step reaction with 16 steps

1: 96 percent

2: 62 percent / CrO₃, 3,5-dimethylpyrazole

3: Li, liq. NH₃ / ethanol

4: 93 percent / LAH

5: n-BuLi

6: n-Bu₃SnH, AIBN

7: PTSA

8: 2,6-Lutidine

9: 97 percent

10: SOCl₂, Py

11: TBAF / tetrahydrofuran

12: (COCl)2, DMSO, Et₃N

13: 97 percent

14: 92 percent / Py

15: 89 percent / Li / liquid ammonia

16: 1.) O₂, Rose Bengal, 2.) Hunig base / 1.) irradiation

With pyridine; 2,6-dimethylpyridine; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; ammonia; oxygen; tri-n-butyl-tin hydride; lithium; rose bengal; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; ammonia;
DOI:10.1016/0040-4039(94)88279-7