1-(1-Benzyl-1H-pyrazol-4-yl)-ethanone

Base Information

• Chemical Name: 1-(1-Benzyl-1H-pyrazol-4-yl)-ethanone
• CAS No.: 1188263-60-6
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Mol file: 1188263-60-6.mol

Synonyms:1-(1-benzyl-1H-pyrazol-4-yl)ethan-1-one

Chemical Property of 1-(1-Benzyl-1H-pyrazol-4-yl)-ethanone

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1-(1-Benzyl-1H-pyrazol-4-yl)-ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-(1-Benzyl-1H-pyrazol-4-yl)-ethanone can be used as c-Met inhibitors to treat cancer.

Technology Process of 1-(1-Benzyl-1H-pyrazol-4-yl)-ethanone

There total 3 articles about 1-(1-Benzyl-1H-pyrazol-4-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

1-benzylpyrazole (10199-67-4) + acetic anhydride (108-24-7) → 1-(1-benzyl-1H-pyrazol-4-yl)ethan-1-one (1188263-60-6)

Guidance literature:

With tin(ll) chloride; In tetrachloromethane; Reflux;

DOI:10.1248/cpb.c12-00725

Reference yield:

benzyl bromide (100-39-0) + 1-(1H-pyrazol-4-yl)ethanone (25016-16-4) → 1-(1-benzyl-1H-pyrazol-4-yl)ethan-1-one (1188263-60-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

→ 1-(1-benzyl-1H-pyrazol-4-yl)ethan-1-one (1188263-60-6)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium carbonate; In butan-1-ol; for 4h; Inert atmosphere; Reflux;

upstream raw materials:

1-benzylpyrazole

acetic anhydride

benzyl bromide

1-(1H-pyrazol-4-yl)ethanone

Downstream raw materials:

6-((6-(1-benzyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline

6-(1-benzyl-1H-pyrazol-4-yl)-3-hydrazinyl-1,2,4-triazine

6-(1-benzyl-1H-pyrazol-4-yl)-3-(methylthio)-1,2,4-triazine

2,2-diethoxy-1-[(1-benzyl)-1H-4-pyrazolyl]ethanone