(E)-2-(4-(methylsulfonyl)styryl)thiophene

Base Information

Chemical Name:(E)-2-(4-(methylsulfonyl)styryl)thiophene
CAS No.:1259295-36-7
Molecular Formula:C₁₃H₁₂O₂S₂
Molecular Weight:264.369
Hs Code.:

Synonyms:(E)-2-(4-(methylsulfonyl)styryl)thiophene

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Chemical Property of (E)-2-(4-(methylsulfonyl)styryl)thiophene

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Technology Process of (E)-2-(4-(methylsulfonyl)styryl)thiophene

There total 5 articles about (E)-2-(4-(methylsulfonyl)styryl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1003-09-4
2-bromothiophene

: (E)-1-(2-bromovinyl)-4-(methylsulfonyl)benzene

: 1259295-36-7
(E)-2-(4-(methylsulfonyl)styryl)thiophene

Guidance literature:: With potassium fluoride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; N,N-dimethyl acetamide; 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; zinc; at 0 - 20 ℃; for 15h; chemoselective reaction; Schlenk technique; Sealed tube; Inert atmosphere;
DOI:10.1002/anie.201607959

Reference yield:

: 5398-77-6
para-methanesulfonylbenzaldehyde

: 1259295-36-7
(E)-2-(4-(methylsulfonyl)styryl)thiophene

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: Dimethyl phosphite; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: sodium hydroxide / isopropyl alcohol / 1.5 h / Reflux; Inert atmosphere

4: zinc; 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium fluoride; N,N-dimethyl acetamide / 15 h / 0 - 20 °C / Schlenk technique; Sealed tube; Inert atmosphere

With potassium fluoride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; N,N-dimethyl acetamide; triethylamine; Dimethyl phosphite; triphenylphosphine; 4,4'-di-tert-butyl-2,2'-bipyridine; sodium hydroxide; magnesium chloride; zinc; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/anie.201607959