5398-77-6

Basic information

• Product Name: 4-Methylsulphonyl benzaldehyde
• Synonyms: 4-METHYLSULPHONYLBENZALDEHYDE: 4-(METHYLSULFONYL)BENZALDEHYDE;4-Mesylbenzaldehyde;4-Methylsulphonyl benzaldehyde,95%;4-Methylsulphonyl be;4-Methylsulphonyl benzaldehyde, 95% 2.5GR;4-Formylphenyl methyl sulphone;Benzaldehyde,4-(Methylsulfonyl)-;Of thiaMphenicol benzaldehyde
• CAS NO: 5398-77-6
• Molecular Formula: C₈H₈O₃S
• Molecular Weight: 184.21
• EINECS: 1312995-182-4
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds;Carbonyl Compounds;Aromatic Aldehydes & Derivatives (substituted);Aldehydes;Phenyls & Phenyl-Het;Benzaldehyde;Phenyls & Phenyl-Het;Intermediate product of Veterinary Thiamphenicol
• Mol File: 5398-77-6.mol
• Article Data: 79

Chemical Properties

• Melting Point: 155-161 °C
• Boiling Point: 288.16°C (rough estimate)
• Flash Point: 242.1°C
• Appearance: Light yellow-beige to light brown/Crystalline Powder or Crystals
• Density: 1.3761 (rough estimate)
• Vapor Pressure: 6.35E-06mmHg at 25°C
• Refractive Index: 1.5151 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform, Methanol
• Stability: Hygroscopic
• CAS DataBase Reference: 4-Methylsulphonyl benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylsulphonyl benzaldehyde(5398-77-6)
• EPA Substance Registry System: 4-Methylsulphonyl benzaldehyde(5398-77-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 24/25-26
• Hazardous Substances Data: 5398-77-6(Hazardous Substances Data)

Usage

Chemical Properties

light yellow-beige to light brown crystalline

Uses

4-(Methylsulfonyl)benzaldehyde has been used in the preparation of arylidene-thiazolidinedione derivatives for the treatment of type 2 diabetes.

InChI:InChI=1/C8H8O3S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-6H,1H3

Upstream product

• 7722-84-1 dihydrogen peroxide 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 3185-99-7 Methyl p-tolyl sulfone 
• 73231-34-2 Florfenicol 
• 555-16-8 4-nitrobenzaldehdye 
• 556-18-3 4-aminobenzaldehyde 
• 31925-27-6 DL-threo-p-methylsulfonylphenylserine ethyl ester 
• 20277-69-4 sodium methansulfinate 
• 104-88-1 4-chlorobenzaldehyde 
• 710-24-7 4-acetamidobenzenesulfinic acid 
• 5470-49-5 4-methanesulfonylphenylamine 
• 22821-80-3 N-(4-methanesulfonylphenyl)acetamide 
• 106-45-6 para-thiocresol 
• 623-13-2 4-methylphenyl methylsulfide 

Downstream Products

• 106473-58-9 isonicotinic acid-(4-methanesulfonyl-benzylidenehydrazide) 
• 102654-34-2 2-(4-methanesulfonyl-phenyl)-[1,3]oxathiolane 
• 137473-27-9 ethyl (2E)-3-[4-(methylsulfonyl)phenyl]acrylate 
• 143426-39-5 2-<4-(Methylsulfonyl)phenyl>-1,3-benzimidazol 
• 1084328-40-4 C₁₇H₁₉N₃O₅S 
• 1084328-28-8 C₁₅H₁₅N₃O₅S 
• 1084328-39-1 C₁₉H₂₃N₃O₅S 
• 1017241-28-9 C₁₅H₁₈N₂O₅S 
• 1080675-79-1 3-(4-methanesulfonyl-phenyl)-1-[6-methyl-2-(3-nitrophenylamino)-pyridin-3-yl]-propenone 
• 1034653-83-2 [6-cyano-3-(4-methanesulfonyl-benzyl)-2-methyl-indolizin-1-yl]acetic acid ethyl ester 

Relevant articles and documents

COMPOSITES, METHODS AND USES THEREOF

The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.

4CzIPN catalyzed photochemical oxidation of benzylic alcohols

A green photoredox oxidation of benzylic primary and secondary alcohols to aldehydes and ketones with air as an oxidant was reported. The oxidation shows broad substrate scope and excellent selectivity over benzylic alcohols to the aliphatic alcohols. Further mechanistic studies revealed a quinuclidine mediated HAT process, and blue LEDs promoted 4CzlPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) photoredox cycle were involved in our oxidation.

Selective synthesis of sulfoxides and sulfonesviacontrollable oxidation of sulfides withN-fluorobenzenesulfonimide

A practical and mild method for the switchable synthesis of sulfoxides or sulfonesviaselective oxidation of sulfides using cheapN-fluorobenzenesulfonimide (NFSI) as the oxidant has been developed. These highly chemoselective transformations were simply achieved by varying the NFSI loading with H2O as the green solvent and oxygen source without any additives. The good functional group tolerance makes the strategy valuable.