N-(5-methoxy-indol-3-yl-phenylmethyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(5-methoxy-indol-3-yl-phenylmethyl)-4-methylbenzenesulfonamide
• CAS No.: 929050-90-8
• Molecular Formula: C₂₃H₂₂N₂O₃S
• Molecular Weight: 406.505
• Mol file: 929050-90-8.mol

Synonyms:N-(5-methoxy-indol-3-yl-phenylmethyl)-4-methylbenzenesulfonamide

Chemical Property of N-(5-methoxy-indol-3-yl-phenylmethyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(5-methoxy-indol-3-yl-phenylmethyl)-4-methylbenzenesulfonamide

There total 2 articles about N-(5-methoxy-indol-3-yl-phenylmethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-methoxylindole (1006-94-6) + N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) → N-(5-methoxy-indol-3-yl-phenylmethyl)-4-methylbenzenesulfonamide (929050-90-8)

Guidance literature:

N-(benzylidene)-p-methylbenzenesulfonamide; With 3,3’-bis[3,5-bis(perfluoropropan-2-yl)phenyl]-1,1’-binaphthalene-2,2’-sulfonimide; In toluene; at -50 ℃; for 0.25h; Inert atmosphere;

5-methoxylindole; In toluene; at -50 ℃; for 3.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo2011335

Reference yield:

5-methoxylindole (1006-94-6) + N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) → (S)-N-((5-methoxy-1H-indol-3-yl)(phenyl)methyl)-4-methylbenzenesulfonamide + N-(5-methoxy-indol-3-yl-phenylmethyl)-4-methylbenzenesulfonamide (929050-90-8) + 5-methoxy-3-((5-methoxy-1H-indol-3-yl)(phenyl)methyl)-1H-indole

Guidance literature:

N-(benzylidene)-p-methylbenzenesulfonamide; With 3,3’-bis[3,5-bis(perfluoropropan-2-yl)phenyl]-1,1’-binaphthalene-2,2’-sulfonimide; In toluene; at 60 ℃; Inert atmosphere;

5-methoxylindole; In toluene; at 60 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo2011335

upstream raw materials:

5-methoxylindole

N-(benzylidene)-p-methylbenzenesulfonamide