(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

Base Information

Chemical Name:(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine
CAS No.:1232788-41-8
Molecular Formula:C₁₇H₁₉BrN₆
Molecular Weight:387.282
Hs Code.:

Synonyms:(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

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Chemical Property of (7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

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Technology Process of (7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

There total 2 articles about (7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 16153-81-4
4-(4-Methyl-piperazino)-anilin

: 1233184-54-7
7-bromo-2-(methylsulfinyl)pyrrolo[2, 1-f][1,2,4]triazine

: 1232788-41-8
(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 135 ℃; for 7h;

Reference yield:

: 1233094-95-5
7-bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232788-41-8
(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; aniline; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/jm200758k

Reference yield: 48.0%

: 1232788-41-8
(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

: 2-(aminocarbonyl)benzeneboronic acid

: 1232400-39-3
2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm200758k