2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide

Base Information

Chemical Name:2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide
CAS No.:1232400-39-3
Molecular Formula:C₂₄H₂₅N₇O
Molecular Weight:427.509
Hs Code.:

Synonyms:2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide

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Chemical Property of 2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide

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Technology Process of 2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide

There total 3 articles about 2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1232788-41-8
(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

: 2-(aminocarbonyl)benzeneboronic acid

: 1232400-39-3
2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm200758k

Reference yield:

: 1233094-95-5
7-bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232400-39-3
2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

3: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; aniline; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/jm200758k

Reference yield:

: 1233184-54-7
7-bromo-2-(methylsulfinyl)pyrrolo[2, 1-f][1,2,4]triazine

: 1232400-39-3
2-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

2: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; aniline; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm200758k