tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate

Base Information

Chemical Name:tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate
CAS No.:168134-60-9
Molecular Formula:C₂₀H₃₆O₃Si₂
Molecular Weight:380.675
Hs Code.:

Synonyms:tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate

Suppliers and Price of tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
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Technology Process of tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate

There total 1 articles about tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 17199-29-0
(S)-Mandelic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 168134-60-9
tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 84h; Ambient temperature;
DOI:10.1016/0957-4166(95)00201-Y

Reference yield:

: 168134-60-9
tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate

: 168134-61-0
(2S)-O-(tert-butyldimethylsilyl)mandelolyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/0957-4166(95)00201-Y

Reference yield:

: 168134-60-9
tert-butyldimethylsilyl (2S)-(O-tert-butyldimethylsilyl)mandelate

: O^α-(tert-butyldimethylsilyl)-L-mandeloyl-L-mandeloyl-L-mandeloyl-L-mandelic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 237 mg / aq. NaOH / 1.75 h

2: 4 percent / diisopropylcarbodiimide; 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 20 °C

With dmap; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; 1: Hydrolysis / 2: Esterification;
DOI:10.1021/jo981580+