5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine

Base Information

Chemical Name:5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine
CAS No.:1454333-41-5
Molecular Formula:C₃₉H₆₃IN₂O₁₃Si
Molecular Weight:922.925
Hs Code.:

Synonyms:5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine

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Chemical Property of 5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine

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Technology Process of 5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine

There total 4 articles about 5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1454333-37-9
3,6,9,12,15,18-hexaoxaicos-19-en-1-yl benzoate

: 129696-31-7
5-iodo-5′-O-triisopropylsilyl-2′-deoxyuridine

: 1454333-41-5
5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine

Guidance literature:: With camphor-10-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1039/c3ob41428k

Reference yield:

: 98-88-4
benzoyl chloride

: 1454333-41-5
5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 16 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 20 °C

2.2: 20 h / Reflux

3.1: camphor-10-sulfonic acid / tetrahydrofuran / 18 h / 20 °C

With dmap; camphor-10-sulfonic acid; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1039/c3ob41428k

Reference yield:

: 929-37-3
2-[2-(ethenyloxy)ethoxy]ethan-1-ol

: 1454333-41-5
5-iodo-3’-O-(1-methyl-21-oxo-21-phenyl-2,5,8,11,14,17,20-heptaoxahenicos-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / 0.17 h

1.2: 0.05 h

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 20 °C

2.2: 20 h / Reflux

3.1: camphor-10-sulfonic acid / tetrahydrofuran / 18 h / 20 °C

With camphor-10-sulfonic acid; sodium hydride; potassium carbonate; In tetrahydrofuran; mineral oil;
DOI:10.1039/c3ob41428k