(4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester

Base Information

Chemical Name:(4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester
CAS No.:261367-93-5
Molecular Formula:C₂₀H₃₁N₃O₇S
Molecular Weight:457.548
Hs Code.:

(4-<i>tert</i>-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester

Synonyms:(4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester

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Chemical Property of (4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester

Chemical Property:

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Technology Process of (4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester

There total 4 articles about (4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 261367-93-5
(4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / aq. K₂CO₃ / dioxane

2: EDC*HCl; HOBt; DIEA / dimethylformamide

3: 100 percent / H₂; 1 N HCl / Pd/C / ethanol

4: NMM / acetonitrile

With 4-methyl-morpholine; hydrogenchloride; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile; 1: Acylation / 2: Condensation / 3: Hydrogenolysis / 4: Tosylation;
DOI:10.1016/S0960-894X(99)00628-9

Reference yield:

: 214852-60-5
2-benzyloxycarbonylamino-4-tert-butoxycarbonylamino-butyric acid

: 261367-93-5
(4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EDC*HCl; HOBt; DIEA / dimethylformamide

2: 100 percent / H₂; 1 N HCl / Pd/C / ethanol

3: NMM / acetonitrile

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; acetonitrile; 1: Condensation / 2: Hydrogenolysis / 3: Tosylation;
DOI:10.1016/S0960-894X(99)00628-9

Reference yield:

: 261367-87-7
(2-benzyloxycarbonylamino-4-tert-butoxycarbonylamino-butyrylamino)-acetic acid ethyl ester

: 261367-93-5
(4-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-butyrylamino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂; 1 N HCl / Pd/C / ethanol

2: NMM / acetonitrile

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; acetonitrile; 1: Hydrogenolysis / 2: Tosylation;
DOI:10.1016/S0960-894X(99)00628-9