1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone

Base Information

Chemical Name:1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone
CAS No.:1026484-23-0
Molecular Formula:C₂₀H₂₀F₃NO₆S₂
Molecular Weight:491.509
Hs Code.:

Synonyms:1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone

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Chemical Property of 1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone

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Technology Process of 1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone

There total 8 articles about 1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1026484-23-0
1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone

Guidance literature:

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 1026484-23-0
1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone

Guidance literature:: Multi-step reaction with 7 steps

1.1: t-BuOK / pyridine / 1 h / 100 °C

2.1: H₂ / 10percent Pd/C / methanol / 3 h / 3040.2 Torr

3.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

3.2: aq. HCl / 1 h / 70 °C

4.1: KOH / ethanol / 2 h / 80 °C

5.1: KOH / ethanol / 19 h / 23 - 80 °C

6.1: thionyl chloride / 16 h / 23 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -25 °C

7.2: tetrahydrofuran; hexane / 16 h / -78 °C

With hydrogenchloride; potassium hydroxide; n-butyllithium; thionyl chloride; potassium tert-butylate; hydrogen; sodium nitrite; 10percent Pd/C; In tetrahydrofuran; pyridine; methanol; ethanol; hexane;
DOI:10.1021/jm0103920

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1026484-23-0
1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone

Guidance literature:: Multi-step reaction with 7 steps

1.1: t-BuOK / pyridine / 1 h / 100 °C

2.1: H₂ / 10percent Pd/C / methanol / 3 h / 3040.2 Torr

3.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

3.2: aq. HCl / 1 h / 70 °C

4.1: KOH / ethanol / 2 h / 80 °C

5.1: KOH / ethanol / 19 h / 23 - 80 °C

6.1: thionyl chloride / 16 h / 23 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -25 °C

7.2: tetrahydrofuran; hexane / 16 h / -78 °C

With hydrogenchloride; potassium hydroxide; n-butyllithium; thionyl chloride; potassium tert-butylate; hydrogen; sodium nitrite; 10percent Pd/C; In tetrahydrofuran; pyridine; methanol; ethanol; hexane;
DOI:10.1021/jm0103920