4-Methanesulfonyl morpholine

Base Information

• Chemical Name: 4-Methanesulfonyl morpholine
• CAS No.: 1697-34-3
• Molecular Formula: C5H11NO3S
• Molecular Weight: 165.213
• Hs Code.: 2934999090
• Mol file: 1697-34-3.mol

Synonyms:methyl morpholino sulfone;4-Methansulfonyl-morpholin;4-(methylsulfonyl)morpholine;N-methanesulfonyl morpholine;Morpholine, 4-(methylsulfonyl)-;Morpholine,4-(methylsulfonyl);N-(methylsulfonyl) morpholine;4-methanesulfonyl-morpholine;Morpholine methane sulfonic acid amide;

Chemical Property of 4-Methanesulfonyl morpholine

Chemical Property:

• PSA: 54.99000
• LogP: 0.29690

Purity/Quality:

97% ^*data from raw suppliers

4-methanesulfonylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methanesulfonyl morpholine

There total 10 articles about 4-Methanesulfonyl morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(trimethylsilyl)morpholine (13368-42-8) + methanesulfonyl chloride (124-63-0) → 4-methanesulfonylmorpholine (1697-34-3)

Guidance literature:

In acetonitrile; for 1h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.08.034

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + sodium methansulfinate (20277-69-4) → 4-methanesulfonylmorpholine (1697-34-3)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; acetonitrile; at 50 ℃; for 8h;

DOI:10.1039/c4ra13454k

Reference yield: 95.0%

→ 4-methanesulfonylmorpholine (1697-34-3)

Guidance literature:

With 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; tetrabutylammonium triphenyldifluorosilicate; In dichloromethane; at 20 ℃; Glovebox; Inert atmosphere;

upstream raw materials:

morpholine

methanesulfonyl chloride

methyl α-disulfone

N-nitromethanesulfonimide

Downstream raw materials:

N-[(2-Phenyloxo-2-ethane)sulphonyl]morpholine

(morpholinosulphonylmethyl)-(4-fluorophenyl)-ketone

1-(4-Chloro-phenyl)-2-(morpholine-4-sulfonyl)-ethanone

1-(4-Methoxy-phenyl)-2-(morpholine-4-sulfonyl)-ethanone

Refernces

• 1、 Sarkar, Debayan,Ghosh, Manoj Kumar,Rout, Nilendri. "PTAB mediated open air synthesis of sulfonamides, thiosulfonates and symmetrical disulfanes". supporting information. p. 2360 - 2364. Retrieved 2018/05/24.
• 2、 -. "Process for the Synthesis of Sulfones and Sulfonamides". Paragraph 0268; 0269; 0270; 0271; 0272. . Retrieved 2017/07/06.