2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine

Base Information

Chemical Name:2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine
CAS No.:1300590-34-4
Molecular Formula:C₄₄H₅₀N₂O₈Si
Molecular Weight:762.975
Hs Code.:

Synonyms:2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine

Suppliers and Price of 2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine

There total 7 articles about 2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1300590-32-2
3,5-di-O-benzyl-4-C-(2-t-butyldiphenylsilyloxyethyl)1,2-di-O-acetyl-α-D-erythropentofuranose

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1300590-34-4
2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine

Guidance literature:: 3,5-di-O-benzyl-4-C-(2-t-butyldiphenylsilyloxyethyl)1,2-di-O-acetyl-α-D-erythropentofuranose; thymin; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; for 1.5h; Inert atmosphere; Reflux;

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 0 ℃; for 3.5h; Reflux; Inert atmosphere;

Reference yield: 74.0%

: 3,5-di-O-benzyl-4-(2-t-butyldiphenylsilyloxyethyl)-1,2-di-O-acetyl-α-D-erythropentofuranose

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1300590-34-4
2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine

Guidance literature:: 3,5-di-O-benzyl-4-(2-t-butyldiphenylsilyloxyethyl)-1,2-di-O-acetyl-α-D-erythropentofuranose; thymin; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; for 1h; Inert atmosphere; Reflux;

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 0.666667h; Reflux;

Reference yield:

: 287737-62-6
2-((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethanol

: 1300590-34-4
2’-O-acetyl-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyluridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: acetic anhydride; sulfuric acid; acetic acid / 2 h / 20 °C / Inert atmosphere

3.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1.5 h / Inert atmosphere; Reflux

3.2: 3.5 h / 0 °C / Reflux; Inert atmosphere

With dmap; N,O-bis-(trimethylsilyl)-acetamide; sulfuric acid; acetic anhydride; acetic acid; triethylamine; In dichloromethane; acetonitrile;