5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

Base Information

Chemical Name:5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline
CAS No.:907999-09-1
Molecular Formula:C₂₇H₂₇N₃O₂
Molecular Weight:425.53
Hs Code.:

Synonyms:5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

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Chemical Property of 5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

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Technology Process of 5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

There total 6 articles about 5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 907999-05-7
3-acetyl-1-benzyl-7-methoxy-2,3-dihydro-1H-quinolin-4-one

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 907999-09-1
5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

Guidance literature:: In tetrahydrofuran; N,N-dimethyl-formamide; Heating;
DOI:10.1055/s-2006-926466

Reference yield:

: 33240-22-1
3-(3-methoxyphenylamino)but-2-enoic acid ethyl ester

: 907999-09-1
5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: 73 percent / H₂ / Pd/C / methanol / 8 h / 760.05 Torr

2.1: 73 percent / PPA / 2 h / 90 °C

3.1: 84 percent / K₂CO₃ / dimethylformamide / 60 °C

4.1: LHMDS / tetrahydrofuran / 0.25 h

4.2: 78 percent / tetrahydrofuran / 0.5 h

5.1: 81 percent / dimethylformamide; tetrahydrofuran / Heating

With hydrogen; potassium carbonate; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-926466

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 907999-09-1
5-benzyl-7-methoxy-2-(4-methoxyphenyl)-3,4-dimethyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 79 percent / AcOH

2.1: 73 percent / H₂ / Pd/C / methanol / 8 h / 760.05 Torr

3.1: 73 percent / PPA / 2 h / 90 °C

4.1: 84 percent / K₂CO₃ / dimethylformamide / 60 °C

5.1: LHMDS / tetrahydrofuran / 0.25 h

5.2: 78 percent / tetrahydrofuran / 0.5 h

6.1: 81 percent / dimethylformamide; tetrahydrofuran / Heating

With hydrogen; potassium carbonate; acetic acid; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-926466