9-adenine

Base Information

• Chemical Name: 9-adenine
• CAS No.: 220845-71-6
• Molecular Formula: C₂₄H₂₅N₅O₂
• Molecular Weight: 415.495
• Mol file: 220845-71-6.mol

Synonyms:9-adenine

Chemical Property of 9-adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-adenine

There total 8 articles about 9-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

9--6-chloropurine (220845-70-5) → 9-adenine (220845-71-6)

Guidance literature:

With ammonia; In methanol; at 80 ℃; for 24h;

DOI:10.1016/S0040-4020(98)01120-X

Reference yield:

4,6-dichloro-5-formamidopyrimidine (123240-66-4) → 9-adenine (220845-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / Et₃N / dioxane / 8 h / Heating

2: 1.) MeCOCH(OEt)2, 2.) NH₄OH / 1.) 120 deg C, 22 h, 2.) MeOH, H₂O, rt, 1 h

3: 73 percent / NH₃ / methanol / 24 h / 80 °C

With ammonium hydroxide; methylglyoxal diethyl acetal; ammonia; triethylamine; In 1,4-dioxane; methanol;

DOI:10.1016/S0040-4020(98)01120-X

Reference yield:

(1S,2R,3S)-2,3-Bis-benzyloxymethyl-cyclopropanecarbaldehyde (172688-27-6) → 9-adenine (220845-71-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 71 percent / Jones' reagent / acetone / 10 h / -5 °C

2: 1.) ClCO₂Et, Et₃N, 2.) NH₃ / 1.) THF, -5 deg C, 1 h, 2.) THF, 0 deg C, 1 h

3: 78 percent / KOH, PhI(OAc)2 / 1 h / 5 - 20 °C

4: 83 percent / KOH / methanol / 48 h / Heating

5: 50 percent / Et₃N / dioxane / 8 h / Heating

6: 1.) MeCOCH(OEt)2, 2.) NH₄OH / 1.) 120 deg C, 22 h, 2.) MeOH, H₂O, rt, 1 h

7: 73 percent / NH₃ / methanol / 24 h / 80 °C

With potassium hydroxide; ammonium hydroxide; jones' reagent; methylglyoxal diethyl acetal; [bis(acetoxy)iodo]benzene; ammonia; chloroformic acid ethyl ester; triethylamine; In 1,4-dioxane; methanol; acetone;

DOI:10.1016/S0040-4020(98)01120-X

upstream raw materials:

9--6-chloropurine

4,6-dichloro-5-formamidopyrimidine

(1S,2R,3S)-2,3-Bis-benzyloxymethyl-cyclopropanecarbaldehyde

cis-2,cis-3-bis(benzyloxymethyl)cyclopropylamine