9-adenine

Base Information

Chemical Name:9-adenine
CAS No.:220845-71-6
Molecular Formula:C₂₄H₂₅N₅O₂
Molecular Weight:415.495
Hs Code.:

9-<cis-2',cis-3'-bis(benzyloxymethyl)cyclopropyl>adenine

Synonyms:9-adenine

Suppliers and Price of 9-adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-adenine

Chemical Property:

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Technology Process of 9-adenine

There total 8 articles about 9-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 220845-70-5
9--6-chloropurine

: 220845-71-6
9-adenine

Guidance literature:: With ammonia; In methanol; at 80 ℃; for 24h;
DOI:10.1016/S0040-4020(98)01120-X

Reference yield:

: 123240-66-4
4,6-dichloro-5-formamidopyrimidine

: 220845-71-6
9-adenine

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / Et₃N / dioxane / 8 h / Heating

2: 1.) MeCOCH(OEt)2, 2.) NH₄OH / 1.) 120 deg C, 22 h, 2.) MeOH, H₂O, rt, 1 h

3: 73 percent / NH₃ / methanol / 24 h / 80 °C

With ammonium hydroxide; methylglyoxal diethyl acetal; ammonia; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1016/S0040-4020(98)01120-X

Reference yield:

: 172688-27-6
(1S,2R,3S)-2,3-Bis-benzyloxymethyl-cyclopropanecarbaldehyde

: 220845-71-6
9-adenine

Guidance literature:: Multi-step reaction with 7 steps

1: 71 percent / Jones' reagent / acetone / 10 h / -5 °C

2: 1.) ClCO₂Et, Et₃N, 2.) NH₃ / 1.) THF, -5 deg C, 1 h, 2.) THF, 0 deg C, 1 h

3: 78 percent / KOH, PhI(OAc)2 / 1 h / 5 - 20 °C

4: 83 percent / KOH / methanol / 48 h / Heating

5: 50 percent / Et₃N / dioxane / 8 h / Heating

6: 1.) MeCOCH(OEt)2, 2.) NH₄OH / 1.) 120 deg C, 22 h, 2.) MeOH, H₂O, rt, 1 h

7: 73 percent / NH₃ / methanol / 24 h / 80 °C

With potassium hydroxide; ammonium hydroxide; jones' reagent; methylglyoxal diethyl acetal; [bis(acetoxy)iodo]benzene; ammonia; chloroformic acid ethyl ester; triethylamine; In 1,4-dioxane; methanol; acetone;
DOI:10.1016/S0040-4020(98)01120-X