123240-66-4

Basic information

• Product Name: N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE
• Synonyms: AKOS 91530;N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE;4,6-Dichloro-5-formamidopyrimidine;N-(4,6-Dichloropyrimidin-5-yl)
• CAS NO: 123240-66-4
• Molecular Formula: C₅H₃Cl₂N₃O
• Molecular Weight: 192
• Mol File: 123240-66-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE(123240-66-4)
• EPA Substance Registry System: N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE(123240-66-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 123240-66-4(Hazardous Substances Data)

Usage

General Description

N-(4,6-dichloro-pyrimidin-5-yl)-formamide is a chemical compound that is used in pharmaceutical and agrochemical applications. It is a formamide derivative with a pyrimidine ring structure, and the presence of chloro substituents at positions 4 and 6 on the pyrimidine ring. N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE has been studied for its potential as an intermediate in the synthesis of various bioactive molecules, including pharmaceuticals and agrochemicals. It may also have uses in the field of medicinal chemistry for the development of new drugs. The compound's specific properties and potential applications make it a subject of interest for further research and development.

Upstream product

• 64-18-6 formic acid 
• 5413-85-4 5-amino-4,6-dichloropyridimine 

Downstream Products

• 124077-21-0 N-(4-Benzyloxyamino-6-chloro-pyrimidin-5-yl)-formamide 
• 58462-31-0 (1R,2S,3R,5R)-3-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol 
• 57345-51-4 (1S,2R,4R)-4-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)cyclopentan-1-ol 
• 124077-11-8 9-benzyloxy-6-chloropurine 

Relevant articles and documents

Preparation method for tenofovir

The invention relates to the field of chemical synthesis, and in particular relates to a preparation method for tenofovir. The compound provided by the invention has a structure shown by a formula XIIin the description. The method for preparing the tenofovir based on a compound provided by the invention has the advantages that raw materials are cheap and easy to obtain, the process route is short, the conditions are mild and reliable, and the method is easily used for industrialized production.

Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-Hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy]purines

Reaction of hydroxyl-protected derivatives of hydroxyalkoxyamines (3a,b,c) with either 4,6-dichloro-2,5-diformamidopyrimidine (5) or 4,6-dichloro-5-formamidopyrimidine (31) and subsequent cyclization of the resultant 6-(alkoxyamino)pyrimidines (6, 17, 32, 35) by heating with diethoxymethyl acetate afforded 9-alkoxy-6-chloropurines (7, 18, 33, 36), which were converted subsequently to 9-(3-hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy] derivatives of guanine, 2-amino-6-chloropurine, 2-amino-6-alkoxypurines, 2-aminopurine, 2,6-diaminopurine, adenine, hypoxanthine, and 6-methoxypurine (8, 12, 13, 19-21, 23-26, 34, 37-39). Carboxylic acid esters (9-11, 14-16, 27-29) and a cyclic phosphate derivative (22) of the 9-(hydroxyalkoxy)guanines (8, 21) and 2-amino-9-(hydroxyalkoxy)purines (13, 26) were also prepared. The guanine derivatives (8, 21) showed potent and selective activity against herpes simplex virus types 1 and 2 and varicella zoster virus in cell cultures and 8 is more active than acyclovir. Although without significant antiviral activity in cell cultures, the 2-aminopurines (13, 14-16, 26-29) and 2-amino-6-alkoxypurines (12, 23-25) are well absorbed after oral administration to mice and are converted efficiently to the antiviral guanine derivatives (8, 21) in vivo.