methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate

Base Information

Chemical Name:methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate
CAS No.:166326-80-3
Molecular Formula:C₂₄H₂₄F₃NO₉S
Molecular Weight:559.517
Hs Code.:

Synonyms:methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate

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Chemical Property of methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate

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Technology Process of methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate

There total 1 articles about methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 126891-19-8
(2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

: 166326-80-3
methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 1h;

Reference yield: 99.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 166326-80-3
methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate

: methyl (2S,3S,4S)-1,2-dimethoxycarbonyl-4-(2-methoxycarbonylphenyl)-3-pyrrolidineacetate

Guidance literature:: With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In dimethyl sulfoxide; at 80 ℃; for 1.5h;

Reference yield:

: 166326-80-3
methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate

: (2S,3S,4S)-2-carboxy-4-(2-carboxyphenyl)-3-pyrrolidineacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / Et₃N, 1,3-bis(diphenylphosphino)propane, Pd(OAc)2 / dimethylsulfoxide / 1.5 h / 80 °C

2: 1.) 2M aq. KOH, 2.) TMSOTf, thioanisol, TFA / 1.) MeOH, RT, 1 h, 2.) 0 deg C, 1 h

With palladium diacetate; potassium hydroxide; trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether; 1,3-bis-(diphenylphosphino)propane; triethylamine; trifluoroacetic acid; In dimethyl sulfoxide;