(4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid

Base Information

• Chemical Name: (4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid
• CAS No.: 945635-15-4
• Molecular Formula: C₁₈H₂₅NO₇S
• Molecular Weight: 399.465
• Mol file: 945635-15-4.mol

Synonyms:(4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid

Chemical Property of (4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid

There total 8 articles about (4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-hydroxy-3-(3,6,9-trioxadecyloxy)benzonitrile (1037282-58-8) + (2R)-2-methyl-L-cysteine hydrochloride → (4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid (945635-15-4)

Guidance literature:

With sodium hydrogencarbonate; In methanol; at 70 ℃; for 72h; pH=5.95 - 6.6; aq. phosphate buffer;

DOI:10.1021/jm800154m

Reference yield: 90.0%

2-hydroxy-3-(3,6,9-trioxadecyloxy)benzonitrile (1037282-58-8) + (S)-α-methylcysteine hydrochloride → (4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid (945635-15-4)

Guidance literature:

2-hydroxy-3-(3,6,9-trioxadecyloxy)benzonitrile; (S)-α-methylcysteine hydrochloride; With sodium hydrogencarbonate; In methanol; at 70 ℃; for 72h; pH=6.2 - 6.6; Phopshate buffer;

With hydrogenchloride; water; pH=~ 1; Product distribution / selectivity;

Reference yield:

2-cyano-6-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenolate (1443045-62-2) + (S)-α-methylcysteine hydrochloride → (4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid (945635-15-4)

Guidance literature:

With hydrogenchloride; disodium hydrogenphosphate; sodium dihydrogen phosphate monohydrate; sodium hydrogencarbonate; In methanol; water; at 70 ℃; for 4.65h; Inert atmosphere;

upstream raw materials:

ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

(S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylic acid

2-hydroxy-3-(3,6,9-trioxadecyloxy)benzonitrile

2-cyano-6-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenolate

Downstream raw materials:

C₄H₁₀N₂*C₁₈H₂₅NO₇S

C₁₈H₂₄NO₇S^(1-)*Ca⁽²⁺⁾*HO^(1-)

C₁₈H₂₄NO₇S^(1-)*K⁽¹⁺⁾

2-(2-(isobutyryloxy)-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-4(S)-methyl-4,5-dihydrothiazole-4-carboxylic acid