ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

Base Information

Chemical Name:ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate
CAS No.:945635-17-6
Molecular Formula:C₁₃H₁₅NO₄S
Molecular Weight:281.332
Hs Code.:

Synonyms:ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

Chemical Property:

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Technology Process of ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

There total 1 articles about ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 75-03-6
ethyl iodide

: 847355-88-8
(S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylic acid

: 945635-17-6
ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1021/jm070214s

Reference yield: 25.0%

: 945635-17-6
ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

: 112-35-6,95507-80-5
triethylene glucol monomethyl ether

: 945635-19-8
ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1021/jm070214s

Reference yield:

: 945635-17-6
ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

: 945635-15-4
(4,5)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}phenyl)-4-methyl-4,5-dihydrothiazole-1,3-thiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 25 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 8 h / 20 °C

2: 60 percent / NaOH / methanol / 6 h / 20 °C

With sodium hydroxide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; 1: Mitsunobu reaction;
DOI:10.1021/jm070214s