(S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide

Base Information

Chemical Name:(S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide
CAS No.:1609138-51-3
Molecular Formula:C₃₁H₃₁N₃O₆S
Molecular Weight:573.67
Hs Code.:

Synonyms:(S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide

Suppliers and Price of (S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of (S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide

There total 4 articles about (S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1609138-39-7
2-[(S)-2-methyl-1-(3,4,5-trimethoxybenzoylamino)propyl]thiazole-4-carboxylic acid

: 2835-77-0
(2-aminophenyl)(phenyl)methanone

: 1609138-51-3
(S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide

Guidance literature:: 2-[(S)-2-methyl-1-(3,4,5-trimethoxybenzoylamino)propyl]thiazole-4-carboxylic acid; With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 0 ℃; for 0.166667h;

(2-aminophenyl)(phenyl)methanone; In N,N-dimethyl acetamide; at 20 ℃;
DOI:10.1021/jm401966m

Reference yield:

: 1609138-34-2
(S)-2-[2-methyl-1-(3,4,5-trimethoxybenzoylamino)propyl]-thiazole-4-carboxylic acid ethyl ester

: 1609138-51-3
(S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol; water / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol / N,N-dimethyl acetamide / 0.17 h / 0 °C

2.2: 20 °C

With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water;
DOI:10.1021/jm401966m

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 1609138-51-3
(S)-N-(2-benzoylphenyl)-2-(2-methyl-1-(3,4,5-trimethoxybenzamido)propyl)thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol / N,N-dimethyl acetamide / 0.17 h / 0 °C

3.2: 20 °C

With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water;
DOI:10.1021/jm401966m