2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile

Base Information

Chemical Name:2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile
CAS No.:1200798-11-3
Molecular Formula:C₂₂H₁₈F₃N₃O₄
Molecular Weight:445.398
Hs Code.:

Synonyms:2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile

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Chemical Property of 2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile

Chemical Property:

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Technology Process of 2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile

There total 1 articles about 2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 2942-58-7
diethyl cyanophosphonate

: 143796-93-4
2-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride

: 659-28-9
p-trifluoromethoxybenzaldehyde

: 1200798-11-3
2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile

Guidance literature:: diethyl cyanophosphonate; p-trifluoromethoxybenzaldehyde; In tetrahydrofuran; at 20 ℃; for 0.166667h;

2-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride; With triethylamine; In tetrahydrofuran; at 20 - 60 ℃; for 41h;

Reference yield:

: 1200798-11-3
2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile

: C₁₄H₁₆F₃N₃O₂

Guidance literature:: With hydrazine hydrate; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1200798-11-3
2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile

: 1200797-92-7
1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / dichloromethane / 16 h / 20 °C

2: tetrahydrofuran / 14 h / 20 °C

With hydrazine hydrate; In tetrahydrofuran; dichloromethane;