1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea

Base Information

Chemical Name:1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea
CAS No.:1200797-92-7
Molecular Formula:C₂₁H₂₀F₄N₄O₃
Molecular Weight:452.408
Hs Code.:

Synonyms:1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea

Chemical Property:

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Technology Process of 1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea

There total 3 articles about 1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₆F₃N₃O₂

: 1195-45-5
para-fluorophenyl isocyanate

: 1200797-92-7
1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 14h;

Reference yield:

: 143796-93-4
2-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride

: 1200797-92-7
1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0.17 h / 20 °C

1.2: 41 h / 20 - 60 °C

2.1: hydrazine hydrate / dichloromethane / 16 h / 20 °C

3.1: tetrahydrofuran / 14 h / 20 °C

With hydrazine hydrate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1200798-11-3
2-(4-(1,3-dioxoisoindolin-2-yloxy)piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetonitrile

: 1200797-92-7
1-(1-(cyano(4-(trifluoromethoxy)phenyl)methyl)piperidin-4-yloxy)-3-(4-fluorophenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / dichloromethane / 16 h / 20 °C

2: tetrahydrofuran / 14 h / 20 °C

With hydrazine hydrate; In tetrahydrofuran; dichloromethane;