Welcome to LookChem.com Sign In|Join Free
  • or


Diclofenac sodium

Base Information Edit
  • Chemical Name:Diclofenac sodium
  • CAS No.:15307-79-6
  • Deprecated CAS:1147187-62-9
  • Molecular Formula:C14H10Cl2NNaO2
  • Molecular Weight:318.135
  • Hs Code.:29224999
  • European Community (EC) Number:239-346-4
  • UNII:QTG126297Q
  • DSSTox Substance ID:DTXSID3037208
  • NCI Thesaurus Code:C47984
  • Nikkaji Number:J8.556A
  • Pharos Ligand ID:MUDSKU2U2VCB
  • RXCUI:203214
  • Wikidata:Q12430631
  • Mol file:15307-79-6.mol
Diclofenac sodium

Synonyms:Dichlofenal;Diclofenac;Diclofenac Potassium;Diclofenac Sodium;Diclofenac, Sodium;Diclonate P;Diclophenac;Dicrofenac;Feloran;GP 45,840;GP-45,840;GP45,840;Novapirina;Orthofen;Orthophen;Ortofen;Sodium Diclofenac;SR 38;SR-38;SR38;Voltaren;Voltarol

Suppliers and Price of Diclofenac sodium
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Diclofenac sodium salt
  • 50mg
  • $ 50.00
  • Tocris
  • Diclofenac sodium salt ≥99%(HPLC)
  • 50
  • $ 51.00
  • TCI Chemical
  • Diclofenac Sodium Salt >98.0%(HPLC)(N)
  • 25g
  • $ 63.00
  • Sigma-Aldrich
  • Diclofenac sodium salt
  • 10g
  • $ 65.80
  • Sigma-Aldrich
  • Diclofenac sodium salt analytical standard
  • 100mg
  • $ 55.40
  • Sigma-Aldrich
  • Diclofenac sodium salt Pharmaceutical Secondary Standard; Certified Reference Material
  • 1g
  • $ 70.40
  • Sigma-Aldrich
  • Diclofenac Sodium
  • 1gm
  • $ 44.20
  • Sigma-Aldrich
  • Diclofenac sodium European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Diclofenac for system suitability European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Diclofenac for system suitability European Pharmacopoeia (EP) Reference Standard
  • y0001635
  • $ 190.00
Total 321 raw suppliers
Chemical Property of Diclofenac sodium Edit
Chemical Property:
  • Appearance/Colour:white or off-white powder 
  • Melting Point:288-290 °C 
  • Boiling Point:412 °C at 760 mmHg 
  • PKA:4(at 25℃) 
  • Flash Point:203 °C 
  • PSA:52.16000 
  • Density:0.781 g/cm3 
  • LogP:3.10240 
  • Storage Temp.:-20°C Freezer 
  • Solubility.:H2O: 50 mg/mL 
  • Water Solubility.:Soluble in water to 50mg/ml. 
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:4
  • Exact Mass:316.9986282
  • Heavy Atom Count:20
  • Complexity:310

99% *data from raw suppliers

Diclofenac sodium salt *data from reagent suppliers

Safty Information:
  • Pictogram(s): ToxicT,IrritantXi 
  • Hazard Codes:T,Xi 
  • Statements: 25-36/37/38-63 
  • Safety Statements: 22-36/37-45-36-26-60-20 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

  • Canonical SMILES:C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]
  • Recent ClinicalTrials:The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
  • Recent EU Clinical Trials:Randomized, double-blind, parallel-groups, active - and placebo-controlled study to Evaluate the efficacy of a fixed combination of diclofenac 75 mg + thiocolchicoside 4 mg as solution for injection, in reLIEving back pain symptoms. Controlled study vs. dicloFenac 75 mg solution for injection and placebo (RELIEF study).
  • Recent NIPH Clinical Trials:Low dose Rectal diclofenac for prevention of Post-ESD Coagulation Syndrome(LOWER PECS): a randomized controlled trial
  • description Diclofenac Sodium is the sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever.
  • Uses Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of diclofenac sodium (Voltarol ampoules) currently available in Europe contains the solvents propylene glycol and benzyl alcohol that allows intramuscular and intravenous administration. Diclofenac sodium has long been used to treat acute pain and inflammation, and is effective in various acute forms of pain. Diclofenac sodium is a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
  • Description Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
  • Therapeutic Function Antiinflammatory
  • Clinical Use Diclofenac sodium is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
  • Drug interactions Potentially hazardous interactions with other drugs antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).Antibacterials: possibly increased risk of convulsions with quinolones; concentration reduced by rifampicin.Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban; increased risk of haemorrhage with IV diclofenac - avoid.Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.Antidiabetic agents: effects of sulphonylureas enhanced.Antiepileptics: possibly increased phenytoin concentration.Ciclosporin: may potentiate nephrotoxicity; concentration increased by ciclosporin.Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Technology Process of Diclofenac sodium

There total 29 articles about Diclofenac sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With sodium hydroxide; In water; N,N-dimethyl-formamide; at 80 ℃; for 24h;
Guidance literature:
With sodium hydroxide; In ethanol; water; for 4h; Heating;
Guidance literature:
2-aminophenylacetic acid methyl ester; With chloroacetyl chloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 50 - 110 ℃; for 5h; Cooling with ice;
2,6-Dichlorophenol; With sodium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 65 - 110 ℃; for 24h;
Refernces Edit
Post RFQ for Price