35613-44-6Relevant articles and documents
Synthesis process of diclofenac sodium
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, (2021/09/26)
The invention provides a synthesis process of diclofenac sodium, which is obtained by acylation reaction of o-aminobenzene acetate with 2 and 6 - dichlorophenoxy acetic acid respectively and acylation with chlorobenzoyl chloride followed by nucleophilic substitution with 2, 6 - dichlorophenol or 2 and 6 -dichlorophenol. Is hydrolyzed to give sodium diclofenac sodium. The synthesis process is simplified, the reaction condition is mild, and the yield and industrial popularization and application are facilitated.
Gold(I)-Thiolate Oligomers for Catalytic Hydrogenation of Nitroaromatics in Aqueous and Organic Medium
You, Jyun-Guo,Jin, Dun-Yuan,Tseng, Wei-Bin,Tseng, Wei-Lung,Lin, Po-Chiao
, p. 4558 - 4567 (2020/08/19)
Thiolated gold nanoclusters (AuNCs) have been introduced to efficiently and selectively catalyze the hydrogenation of nitroaromatics due to the strong interaction of their S?Au-S staple motifs with the nitro groups of nitroaromatics. However, without a gold core, gold(I)-thiolate oligomers (AuSOs) with S?Au-S staple motifs are rarely explored as catalysts for nitroaromatics. Here, we report a straightforward strategy for the synthesis of AuSOs through hydroxyl radical-induced leaching of glutathione-capped gold nanoparticles (GSH-AuNPs). Raman spectroscopy and matrix-assisted laser desorption/ionization-time of flight mass spectrometry demonstrated that hydroxyl radical-triggered etching of the GSH-AuNPs resulted in the production of AuSOs, including Au4(GSH)7 and Au7(GSH)9. The AuSOs were found to catalyze NaBH4-mediated hydrogenation of 4-nitrophenol to 4-aminophenol with a chemoselectivity of ~100 percent and a normalized rate constant (Knor) of 4.8×105 s? g?1. In addition to the high affinity of the S?Au?S staple motifs for 4-nitrophenol, the unusual catalytic activity of the AuSOs was attributable to the fact that they efficiently catalyzed the production of H2 from NaBH4 and the reaction of dissolved oxygen and NaBH4. The chemoselectivity and applicability of the AuSOs were further verified by performing the catalytic reaction of methyl 2-(2-nitrophenyl) acetate or methyl 4-nitrobenzoate with NaBH4.
A synthesis method of diclofenac (by machine translation)
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Paragraph 0052; 0058; 0059, (2019/10/23)
The present invention provides a diclofenac synthetic method, which belongs to the technical field of drug synthesis; synthetic method of this invention the specific reaction steps are as follows: step 1): compound (a) in the presence of sodium methoxide/methanol reaction, to obtain compound (b); step 2): compound (b) with a compound (c) in the presence of an alkali reaction, to obtain compound (d); step 3): compound (d) with a compound (e) in the organic solvent, under the action of catalyst reaction, to obtain compound (f); the method of raw materials are easy, simple operation, high yield, low cost, less wastes, high safety, is suitable for industrial production. (by machine translation)