6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:71157-96-5
Molecular Formula:C₁₉H₂₂BrNO₃
Molecular Weight:392.293
Hs Code.:

Synonyms:6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of 6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 13 articles about 6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 104113-97-5
N-<2-hydroxy-2-(4-methoxyphenyl)ethyl>-2-(2-bromo-3,4-dimethoxyphenyl)ethylamine

: 71157-96-5
6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With sulfuric acid; trifluoroacetic acid; at 25 ℃; for 3.5h;
DOI:10.1021/jm00161a029

Reference yield:

: 72912-39-1
(2-bromo-3,4-dimethoxyphenyl)acetonitrile

: 71157-96-5
6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / borane / tetrahydrofuran / 1.5 h / Heating

2: 18 percent / 2.5 h / Heating

3: 79 percent / TFA, 36 N aq. H₂SO₄ / 3.5 h / 25 °C

With sulfuric acid; borane; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00161a029

Reference yield:

: 621-59-0
isovanillin

: 71157-96-5
6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 8 steps

1: 36 percent / Br₂

2: 80 percent / K₂CO₃ / dimethylformamide / 0.08 h / Heating

3: NaBH₄ / aq. ethanol / 1 h / 25 °C

4: 12 N aq. HCl

5: dimethylsulfoxide / 1.25 h

6: 60 percent / borane / tetrahydrofuran / 1.5 h / Heating

7: 18 percent / 2.5 h / Heating

8: 79 percent / TFA, 36 N aq. H₂SO₄ / 3.5 h / 25 °C

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; borane; bromine; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00161a029