3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Base Information

Chemical Name:3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine
CAS No.:104421-89-8
Molecular Formula:C₂₂H₂₆BrNO₃
Molecular Weight:432.357
Hs Code.:

Synonyms:3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

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Chemical Property of 3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

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Technology Process of 3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

There total 8 articles about 3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 71157-96-5
6-bromo-7,8-dimethoxy-1-(p-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 106-95-6
allyl bromide

: 104421-89-8
3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: With potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00384a006

Reference yield:

: 33646-40-1
4-methoxymandelonitrile

: 104421-89-8
3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 5 steps

1: 37 percent / BH₃ / tetrahydrofuran

2: 31.6 g / aq. K₂CO₃ / toluene / Ambient temperature

3: BH₃ / tetrahydrofuran / 3 h / Heating

4: conc. H₂SO₄ / trifluoroacetic acid / 0.33 h / Heating

5: 76 percent / K₂CO₃ / dimethylformamide; H₂O; CH₂Cl₂ / Ambient temperature

With sulfuric acid; borane; potassium carbonate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;
DOI:10.1021/jm00384a006

Reference yield:

: 72912-39-1
(2-bromo-3,4-dimethoxyphenyl)acetonitrile

: 104421-89-8
3-Allyl-6-bromo-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / H₂SO₄ / aq. acetic acid / 2 h / Heating

2: SOCl₂ / CH₂Cl₂ / Heating

3: 31.6 g / aq. K₂CO₃ / toluene / Ambient temperature

4: BH₃ / tetrahydrofuran / 3 h / Heating

5: conc. H₂SO₄ / trifluoroacetic acid / 0.33 h / Heating

6: 76 percent / K₂CO₃ / dimethylformamide; H₂O; CH₂Cl₂ / Ambient temperature

With thionyl chloride; sulfuric acid; borane; potassium carbonate; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;
DOI:10.1021/jm00384a006