5-formyl-2,4-dihydroxybenzoic acid

Base Information

• Chemical Name: 5-formyl-2,4-dihydroxybenzoic acid
• CAS No.: 873974-93-7
• Molecular Formula: C₈H₆O₅
• Molecular Weight: 182.133
• Mol file: 873974-93-7.mol

Synonyms:5-formyl-2,4-dihydroxybenzoic acid

Chemical Property of 5-formyl-2,4-dihydroxybenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-formyl-2,4-dihydroxybenzoic acid

There total 8 articles about 5-formyl-2,4-dihydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

4-hydroxysalicylic acid (89-86-1) + hexamethylenetetramine (100-97-0) → 3-formyl-2, 4-dihydroxybenzoic acid (4435-88-5) + 5-formyl-2,4-dihydroxybenzoic acid (873974-93-7)

Guidance literature:

4-hydroxysalicylic acid; hexamethylenetetramine; With copper(I) oxide; In trifluoroacetic acid; for 5h; Reflux;

With hydrogenchloride; In water; at 20 ℃; for 1h; regioselective reaction;

DOI:10.1007/s11164-014-1881-5

Reference yield:

C10H10O5 → 5-formyl-2,4-dihydroxybenzoic acid (873974-93-7)

Guidance literature:

With methanol; lithium hydroxide monohydrate; In tetrahydrofuran; for 24h;

Reference yield:

Thiophene-2-acetic acid (1918-77-0) → 5-formyl-2,4-dihydroxybenzoic acid (873974-93-7)

Guidance literature:

upstream raw materials:

hexamethylenetetramine

methyl 2,4-dihydroxybenzoate

Thiophene-2-acetic acid

4-hydroxysalicylic acid

Downstream raw materials:

2,4-dihydroxy-5-nitrobenzaldehyde

2,4-dihydroxy-3,5-dinitro-benzoic acid

Refernces

• 1、 Fu, Xue-Wen,Pu, Wen-Chen,Zhang, Guo-Lin,Wang, Chun. "Synthesis of salicylaldehydes from phenols via copper-mediated duff reaction". . p. 8147 - 8158. Retrieved 2015/02/19.
• 2、 -. "REACTIVE COUMARIN DERIVATIVES AND THEIR USE IN CELLULAR ANALYSES". . . Retrieved 2012/01/13.