Technology Process of 2-hydroxy-4-methoxy-6-(phenethyl)benzoic acid
There total 6 articles about 2-hydroxy-4-methoxy-6-(phenethyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol; ethyl acetate;
at 25 ℃;
for 6h;
under 3878.71 Torr;
DOI:10.1016/j.tetlet.2019.04.028
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / ethanol; water / 12 h / 25 °C
2.1: sodium tetrahydroborate / ethanol / 24 h / 25 - 50 °C
3.1: sodium hydroxide / propylene glycol / 0.07 h / 180 °C / Microwave irradiation
3.2: pH 2
4.1: boron trichloride / dichloromethane / 0 - 25 °C
5.1: sodium methylate; oxygen / methanol / 48 h / 40 °C
6.1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 6 h / 25 °C / 3878.71 Torr
With
sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; oxygen; sodium methylate; boron trichloride; sodium hydroxide;
In
methanol; propylene glycol; ethanol; dichloromethane; water; ethyl acetate;
1.1: |Knoevenagel Condensation / 4.1: |Friedel-Crafts Acylation;
DOI:10.1016/j.tetlet.2019.04.028
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / ethanol; water / 12 h / 25 °C
2.1: sodium tetrahydroborate / ethanol / 24 h / 25 - 50 °C
3.1: sodium hydroxide / propylene glycol / 0.07 h / 180 °C / Microwave irradiation
3.2: pH 2
4.1: boron trichloride / dichloromethane / 0 - 25 °C
5.1: sodium methylate; oxygen / methanol / 48 h / 40 °C
6.1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 6 h / 25 °C / 3878.71 Torr
With
sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; oxygen; sodium methylate; boron trichloride; sodium hydroxide;
In
methanol; propylene glycol; ethanol; dichloromethane; water; ethyl acetate;
1.1: |Knoevenagel Condensation / 4.1: |Friedel-Crafts Acylation;
DOI:10.1016/j.tetlet.2019.04.028
