6-hydroxy-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

Base Information

• Chemical Name: 6-hydroxy-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile
• CAS No.: 39621-09-5
• Molecular Formula: C₁₂H₈N₂O₂
• Molecular Weight: 212.208
• Mol file: 39621-09-5.mol

Synonyms:6-hydroxy-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

Chemical Property of 6-hydroxy-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-hydroxy-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

There total 21 articles about 6-hydroxy-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

α-polyfunctional arylmethylenemalonitrile derivative (53162-07-5) → 2,6-dihydroxy-4-phenyl-3-cyano-pyridine (39621-09-5)

Guidance literature:

With hydrogenchloride; In ethanol; for 3h; Heating;

DOI:10.1016/S0040-4020(01)00613-5

Reference yield: 70.0%

2-cyano-5-phenyl-3,5-dioxopentanonitrile (341511-83-9) → 2,6-dihydroxy-4-phenyl-3-cyano-pyridine (39621-09-5)

Guidance literature:

With hydrogenchloride; for 0.5h; Heating;

DOI:10.1016/S0040-4020(01)00613-5

Reference yield: 60.0%

4-phenyl-2-oxo-3-(1-pyridino)-5-cyano-3,4-trans-1,2,3,4-tetrahydro-6-pyridinolate (129115-55-5) → 6-hydroxy-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile (39621-09-5)

Guidance literature:

With ammonium acetate; In acetic acid; for 3h; Heating;

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

ethyl 2-cyanoacetate

α-polyfunctional arylmethylenemalonitrile derivative

2-cyano-5-phenyl-3,5-dioxopentanonitrile

Downstream raw materials:

4-cyano-3-phenyl-but-3-enoic acid

2,6-dibromo-4-phenyl-nicotinonitrile

2,6-dihydroxy-4-phenylnicotinonitrile

2-chloro-6-(2-(dimethylamino)ethylamino)-4-phenylnicotinonitrile

Refernces

Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties

10.3906/kim-1711-97

The study focuses on the synthesis, solvatochromism, and biological activity of novel azo dyes that incorporate 2-pyridone and benzimidazole moieties. The azo dyes were synthesized through the diazotization of 4-(1H-benzo[d]imidazol-2-yl)aniline and subsequent coupling with substituted 3-cyano-2-pyridones. The dyes were characterized using UV-Vis, FT-IR, and NMR spectroscopy, as well as elemental analysis. The study explored the solvatochromism of the dyes across various solvents and investigated their tautomeric forms. Biological tests, including MTT assays, revealed that the dyes exhibit good biocompatibility and antiproliferative activity against tumor cell lines MDA-MB-231 and HCT-116, suggesting potential applications in cancer treatment.